Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study

Kořínková, Petra; Bazgier, V.; Oklešťková, Jana; Rárová, L.; Strnad, Miroslav; Kvasnica, Miroslav

doi:https://dx.doi.org/10.1016/j.steroids.2017.08.010

Number of the records: 1

Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study

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SYSNO ASEP	0481221
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Synthesis of novel aryl brassinosteroids through alkene cross-metathesis and preliminary biological study
Author(s)	Kořínková, Petra (UEB-Q)_ORCID Bazgier, V. (CZ) Oklešťková, Jana (UEB-Q)_{RID, ORCID, SAI} Rárová, L. (CZ) Strnad, Miroslav (UEB-Q)_{RID, ORCID} Kvasnica, Miroslav (UEB-Q)_{RID, ORCID}
Number of authors	6
Source Title	Steroids. - : Elsevier - ISSN 0039-128X Roč. 127, NOV (2017), s. 46-55
Number of pages	10 s.
Language	eng - English
Country	US - United States
Keywords	Brassinosteroids ; BRI1 receptor kinase ; Cross-metathesis ; Molecular docking ; Organic synthesis ; Plant bioassays
Subject RIV	CC - Organic Chemistry
OECD category	Organic chemistry
R&D Projects	GJ15-08202Y GA ČR - Czech Science Foundation (CSF)
	LO1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UEB-Q - RVO:61389030
UT WOS	000413607900007
EID SCOPUS	85028510908
DOI	10.1016/j.steroids.2017.08.010
Annotation	A series of phenyl analogues of brassinosteroids was prepared via alkene cross-metathesis using commercially available styrenes and 24-nor-5α-chola-2,22-dien-6-one. All derivatives were successfully docked into the active site of BRI1 using AutoDock Vina. Plant growth promoting activity was measured using the pea inhibition biotest and Arabidopsis root sensitivity assay and then was compared with naturally occuring brassinosteroids. Differences in the production of plant hormone ethylene were also observed in etiolated pea seedlings after treatment with the new and also five known brassinosteroid phenyl analogues. Antiproliferative activity was also studied using normal human fibroblast and human cancer cell lines.
Workplace	Institute of Experimental Botany
Contact	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Year of Publishing	2018

Number of the records: 1