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Unconventional transport routes of soluble and membrane proteins and their role in developmental biology
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SYSNO ASEP 0476650 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Unconventional transport routes of soluble and membrane proteins and their role in developmental biology Author(s) Pompa, A. (IT)
De Marchis, F. (IT)
Pallotta, M. T. (IT)
Benitez-Alfonso, Y. (GB)
Jones, A. (GB)
Schipper, K. (DE)
Moreau, K. (GB)
Žárský, Viktor (UEB-Q) RID, ORCID
Di Sansebastiano, G. P. (IT)
Bellucci, M. (IT)Number of authors 10 Article number 703 Source Title International Journal of Molecular Sciences. - : MDPI
Roč. 18, č. 4 (2017)Number of pages 22 s. Language eng - English Country CH - Switzerland Keywords Autophagy ; Exosomes ; Intercellular channels ; Leaderless proteins ; Protein secretion ; Trafficking mechanisms ; Unconventional secretion Subject RIV EA - Cell Biology OECD category Developmental biology Institutional support UEB-Q - RVO:61389030 UT WOS 000402639400029 EID SCOPUS 85016279096 DOI 10.3390/ijms18040703 Annotation Many proteins and cargoes in eukaryotic cells are secreted through the conventional secretory pathway that brings proteins and membranes from the endoplasmic reticulum to the plasma membrane, passing through various cell compartments, and then the extracellular space. The recent identification of an increasing number of leaderless secreted proteins bypassing the Golgi apparatus unveiled the existence of alternative protein secretion pathways. Moreover, other unconventional routes for secretion of soluble or transmembrane proteins with initial endoplasmic reticulum localization were identified. Furthermore, other proteins normally functioning in conventional membrane traffic or in the biogenesis of unique plant/fungi organelles or in plasmodesmata transport seem to be involved in unconventional secretory pathways. These alternative pathways are functionally related to biotic stress and development, and are becoming more and more important in cell biology studies in yeast, mammalian cells and in plants. The city of Lecce hosted specialists working on mammals, plants and microorganisms for the inaugural meeting on „Unconventional Protein and Membrane Traffic“ (UPMT) during 4–7 October 2016. The main aim of the meeting was to include the highest number of topics, summarized in this report, related to the unconventional transport routes of protein and membranes. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2018
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