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Biological Evaluation of Dipyrromethanes in Cancer Cell Lines: Antiproliferative and Pro-apoptotic Properties
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SYSNO ASEP 0476572 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Biological Evaluation of Dipyrromethanes in Cancer Cell Lines: Antiproliferative and Pro-apoptotic Properties Author(s) Jorda, Radek (UEB-Q) ORCID, RID
Lopes, S. M.M. (PT)
Řezníčková, Eva (UEB-Q) RID, ORCID
Kryštof, Vladimír (UEB-Q) RID, ORCID
Pinho e Melo, T. M.V.D. (PT)Number of authors 5 Source Title ChemMedChem. - : Wiley - ISSN 1860-7179
Roč. 12, č. 9 (2017), s. 701-711Number of pages 11 s. Language eng - English Country DE - Germany Keywords anticancer agents ; apoptosis ; cell cycle ; cytotoxicity ; dipyrromethanes Subject RIV EB - Genetics ; Molecular Biology OECD category Oncology R&D Projects LO1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEB-Q - RVO:61389030 UT WOS 000403005600007 EID SCOPUS 85018630636 DOI 10.1002/cmdc.201700152 Annotation Functionalized dipyrromethanes were synthesized by hetero-Diels–Alder reactions of nitroso- and azoalkenes and screened for their in vitro activity as anticancer agents. The studied dipyrromethanes were tested against leukemia and lymphoma cell lines, and showed GI 50 values in the mid-micromolar range. The pro-apoptotic activities of two candidates, (E)-1-(2′-ethoxycarbonylhydrazono-1′-benzyl-1H-tetrazol-5-yl)-5,5′-diethyldipyrromethane and (E)-1-(2′-p-nitrophenyl-2′-hydroxyiminoethyl)-5-phenyldipyrromethane, and their effects on the cell cycle are described. The latter compound was found to decrease the S-phase cell population in a dose-dependent manner and to irreversibly block cells in the G 2 /M phase. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2018
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