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A chromosome conformation capture ordered sequence of the barley genome
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SYSNO ASEP 0476487 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title A chromosome conformation capture ordered sequence of the barley genome Author(s) Mascher, M. (DE)
Gundlach, H. (DE)
Himmelbach, A. (DE)
Beier, S. (DE)
Twardziok, S. O. (DE)
Wicker, T. (CH)
Šimková, Hana (UEB-Q) RID, ORCID
Staňková, Helena (UEB-Q) RID
Vrána, Jan (UEB-Q) RID, ORCID
Chan, S. (US)
Munoz-Amatrian, M. (US)
Houben, A. (GB)
Doležel, Jaroslav (UEB-Q) RID, ORCID
Ayling, S. (GB)
Lonardi, S. (IT)
Mayer, K.F.X. (DE)
Zhang, G. (US)
Braumann, I. (DK)
Spannagl, M. (DE)
Li, C. (US)
Waugh, R. (GB)
Stein, N. (CH)Number of authors 76 Source Title Nature. - : Palgrave Macmillan - ISSN 0028-0836
Roč. 544, č. 7651 (2017), s. 427-433Number of pages 7 s. Language eng - English Country GB - United Kingdom Keywords bacterial artificial chromosomes ; inverted-repeat elements ; complex-plant genomes ; hi-c ; environmental adaptation ; ltr retrotransposons ; structural variation ; maize genome ; software ; database Subject RIV EB - Genetics ; Molecular Biology OECD category Plant sciences, botany R&D Projects LO1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEB-Q - RVO:61389030 UT WOS 000400051900033 EID SCOPUS 85018282934 DOI 10.1038/nature22043 Annotation Cereal grasses of the Triticeae tribe have been the major food source in temperate regions since the dawn of agriculture. Their large genomes are characterized by a high content of repetitive elements and large pericentromeric regions that are virtually devoid of meiotic recombination. Here we present a high-quality reference genome assembly for barley (Hordeum vulgare L.). We use chromosome conformation capture mapping to derive the linear order of sequences across the pericentromeric space and to investigate the spatial organization of chromatin in the nucleus at megabase resolution. The composition of genes and repetitive elements differs between distal and proximal regions. Gene family analyses reveal lineage-specific duplications of genes involved in the transport of nutrients to developing seeds and the mobilization of carbohydrates in grains. We demonstrate the importance of the barley reference sequence for breeding by inspecting the genomic partitioning of sequence variation in modern elite germplasm, highlighting regions vulnerable to genetic erosion. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2018
Number of the records: 1