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Histone deacetylase inhibitors for the treatment of cancer stem cells
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SYSNO ASEP 0469858 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Histone deacetylase inhibitors for the treatment of cancer stem cells Author(s) Dvořáková, Marcela (UEB-Q) RID, ORCID
Vaněk, Tomáš (UEB-Q) RID, ORCIDNumber of authors 2 Source Title MedChemComm. - : Royal Society of Chemistry - ISSN 2040-2503
Roč. 7, č. 12 (2016), s. 2217-2231Number of pages 15 s. Language eng - English Country GB - United Kingdom Keywords acute myeloid-leukemia ; epithelial-mesenchymal transition ; acute myelogenous leukemia ; tumor-initiating cells ; human aml cells ; breast-cancer ; hdac inhibitors ; sirtuin inhibitors ; colorectal-cancer ; anticancer agents Subject RIV CC - Organic Chemistry R&D Projects LD14128 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEB-Q - RVO:61389030 UT WOS 000390552300002 DOI 10.1039/c6md00297h Annotation Tiny populations of tumor cells are present in solid and hematologic malignancies and are responsible for cancer development, metastasis and limited response to therapy; these are referred to as cancer stem cells (CSCs). CSCs are resistant to standard cancer treatments and are the main cause of tumor relapse. Therefore, the development of new therapeutics to overcome the resistance of CSCs is greatly required. It is known that epigenetic histone modifications (acetylation/deacetylation) play a crucial role in cancer development through regulation of gene expression. Deacetylation of histone and non-histone proteins controls cell proliferation, metabolism and apoptosis as well as DNA repair and differentiation. Thus, histone deacetylase inhibitors (HDACis) are a promising group of anti-cancer agents, showing the ability to induce growth arrest or apoptosis in tumor cells. In this review, we summarize the current knowledge about the prospects of HDACis utilization in the treatment of CSCs. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2017
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