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Brassinosteroids: synthesis and biological activities

SYSNO ASEP	0453066
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Brassinosteroids: synthesis and biological activities
Author(s)	Oklešťková, Jana (UEB-Q)_{RID, ORCID, SAI} Rárová, Lucie (UEB-Q)_{RID, ORCID} Kvasnica, Miroslav (UEB-Q)_{RID, ORCID} Strnad, Miroslav (UEB-Q)_{RID, ORCID}
Source Title	Phytochemistry Reviews. - : Springer - ISSN 1568-7767 Roč. 14, č. 6 (2015), s. 1053-1072
Number of pages	20 s.
Language	eng - English
Country	NL - Netherlands
Keywords	Brassinosteroids ; Chemical synthesis ; Plant biological activity
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	LO1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UEB-Q - RVO:61389030
UT WOS	000365316900013
DOI	10.1007/s11101-015-9446-9
Annotation	Brassinosteroids (BRs) are a relatively recently discovered group of phytohormones that are essential for normal plant growth and development. They participate in regulation of numerous vital physiological processes in plants, such as elongation, germination, photomorphogenesis, immunity and reproductive organ development. Structurally they are very similar to animal steroid hormones and include about 70 polyhydroxylated sterol derivatives. They are found at low levels in practically all plant organs. Recent studies have indicated that BRs have antiproliferative, anticancer, antiangiogenic, antiviral and antibacterial properties in animal cell systems, and thus have potential medical applications. Among others, BRs can inhibit replication of viruses in confluent human cell cultures, sometimes with high selectivity indexes, inducing cytotoxic effects in various types of cancer cells but not normal human cells. Thus, they include promising leads for developing potent new anticancer drugs. The aims of this article are to overview chemical characteristics, biological activities and the potential medical applications of natural BRs.
Workplace	Institute of Experimental Botany
Contact	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Year of Publishing	2016

Number of the records: 1