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Markers of Oxidative Damage of Nucleic Acids and Proteins among Workers Exposed to TiO2 (nano) Particles.
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SYSNO ASEP 0452180 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Markers of Oxidative Damage of Nucleic Acids and Proteins among Workers Exposed to TiO2 (nano) Particles. Author(s) Pelclová, D. (CZ)
Ždímal, Vladimír (UCHP-M) RID, ORCID, SAI
Fenclová, Z. (CZ)
Vlčková, S. (CZ)
Turci, F. (IT)
Corazzari, I. (IT)
Kačer, P. (CZ)
Schwarz, Jaroslav (UCHP-M) RID, ORCID, SAI
Zíková, Naděžda (UCHP-M) RID, ORCID, SAI
Makeš, Otakar (UCHP-M) RID, ORCID, SAI
Syslová, K. (CZ)
Komarc, M. (CZ)
Běláček, J. (CZ)
Navrátil, Tomáš (UFCH-W) RID, ORCID
Machajova, M. (SK)
Zakharov, S. (CZ)Source Title Occupational and Environmental Medicine. - : BMJ group - ISSN 1351-0711
Roč. 73, č. 2 (2016), s. 110-118Number of pages 9 s. Language eng - English Country GB - United Kingdom Keywords nanotechnology ; nucleis acid ; oxidative stress Subject RIV DN - Health Impact of the Environment Quality Subject RIV - cooperation J. Heyrovsky Institute of Physical Chemistry - Physical ; Theoretical Chemistry R&D Projects GBP503/12/G147 GA ČR - Czech Science Foundation (CSF) Institutional support UCHP-M - RVO:67985858 ; UFCH-W - RVO:61388955 UT WOS 000369834300007 EID SCOPUS 84954393296 DOI 10.1136/oemed-2015-103161 Annotation The use of nanotechnology is growing enormously and occupational physicians have an increasing interest in evaluating potential hazards and finding biomarkers of effect in workers exposed to nanoparticles. A study was carried out with 36 workers exposed to (nano)TiO2 pigment and 45 controls. Condensate (EBC) titanium and markers of oxidation of nucleic acids (including 8-hydroxy-2-deoxyguanosine (8-OHdG), 8-hydroxyguanosine (8-OHG), 5-hydroxymethyl uracil (5-OHMeU)) and proteins (such as o-tyrosine (o-Tyr), 3-chlorotyrosine (3-ClTyr) and 3-nitrotyrosine (3-NOTyr)) were analysed from samples of their exhaled breath. In the production workshops, the median total mass 2012 and 2013 TiO2 concentrations were 0.65 and 0.40 mg/m(3), respectively. The median numbers of concentrations measured by the scanning mobility particle sizer (SMPS) and aerodynamic particle sizer (APS) were 1.98*10(4) and 2.32*10(4) particles/cm(3), respectively; and about 80% of those particles were smaller than 100 nm in diameter. In the research workspace, lower aerosol concentrations (0.16 mg/m(3) and 1.32*10(4) particles/cm(3)) were found. Titanium in the EBC was significantly higher in production workers (p<0.001) than in research workers and unexposed controls. Accordingly, most EBC oxidative stress markers, including in the preshift samples, were higher in production workers than in the two other groups. Multiple regression analysis confirmed an association between the production of TiO2 and the levels of studied biomarkers. The concentration of titanium in EBC may serve as a direct exposure marker in workers producing TiO2 pigment; the markers of oxidative stress reflect the local biological effect of (nano)TiO2 in the respiratory tract of the exposed workers. Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2016
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