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In vitro antioxidant and anti-proliferative activity of Ethiopian medicinal plant extracts
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SYSNO ASEP 0448068 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title In vitro antioxidant and anti-proliferative activity of Ethiopian medicinal plant extracts Author(s) Tauchen, J. (CZ)
Doskočil, I. (CZ)
Caffi, C. (BE)
Lulekal, E. (ET)
Maršík, Petr (UEB-Q) RID, ORCID
Havlík, J. (CZ)
Van Damme, P. (BE)
Kokoška, L. (CZ)Source Title Industrial Crops and Products. - : Elsevier - ISSN 0926-6690
Roč. 74, NOV 15 (2015), s. 671-679Number of pages 9 s. Language eng - English Country NL - Netherlands Keywords Antioxidant ; Anticarcinogenic ; Plant extract Subject RIV GM - Food Processing Institutional support UEB-Q - RVO:61389030 UT WOS 000360948900086 DOI 10.1016/j.indcrop.2015.05.068 Annotation Identification and characterization of natural products with antioxidant and anti-proliferative activity has received much interest over the past few years. Ethiopia is one of the developing countries which have enormous diversity of plants and yet majority stays scientifically neglected and undiscovered. In this study, the ethanol extracts of 18 Ethiopian wild medicinal plants were investigated for their in vitro antioxidant and anti-proliferative potential. For this purpose DPPH (2,2-diphenyl-1-picrylhydrazyl), ORAC (oxygen radical absorbance capacity) and TPC (total phenolic content) assays together with MU cell viability assay (performed on Hep-G2 and MRC-5) were used. Extracts of Carissa spinarum, Dodonaea angustifolia, Jasminum abyssinicum, Rumex nepalensis, Rubus steudneri and Verbascum sinaiticum exhibited the most significant results. However, it was discovered that C. spinarum, J. abyssinicum and R. steudneri possessed considerable toxicity against normal MRC-5 cell line. Only extracts of D. angustifolia and R. nepalensis demonstrated significant combinatory antioxidant/anti-proliferative effect, while V. sinaiticum showed best selective anti-proliferative activity. Since aforementioned extracts also exerted low or minimal toxicity to normal cells, we suggest these as prospective material for further development of novel plant-based agents effective against oxidative stress related diseases. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2016
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