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The Effect of LDL-Apheresis and Rheohaemapheresis Treatment on Vitamin E
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SYSNO ASEP 0446930 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The Effect of LDL-Apheresis and Rheohaemapheresis Treatment on Vitamin E Author(s) Solichová, D. (CZ)
Bláha, M. (CZ)
Aufartová, J. (CZ)
Kujovská-Krčmářová, L. (CZ)
Plíšek, J. (CZ)
Honegrová, B. (CZ)
Kasalová, E. (CZ)
Lánská, M. (CZ)
Urbánek, Lubor (UEB-Q) RID
Sobotka, L. (CZ)Source Title Journal of Nutritional Science and Vitaminology - ISSN 0301-4800
Roč. 61, č. 2 (2015), s. 105-112Number of pages 8 s. Language eng - English Country JP - Japan Keywords vitamin E ; LDL-apheresis ; rheohaemapheresis Subject RIV EF - Botanics Institutional support UEB-Q - RVO:61389030 UT WOS 000355020000001 DOI 10.3177/jnsv.61.105 Annotation Lipid apheresis (extracorporeal lipoprotein elimination) is administered to patients with familial hypercholesterolemia who fail to respond to standard therapy. The nature of the treatment process raises the suspicion that it decreases not only cholesterol but also antioxidants. A group of 12 patients (average age 47 +/- 17 y, 4 homozygous and 8 heterozygous individuals) with familial hypercholesterolemia treated by LDL-apheresis or rheohaemapheresis for 3-12 y was included in the study. In addition to cholesterol and triacylglycerol levels, vitamin E and vitamin A and also other markers of antioxidant activity were investigated. Nevertheless, the most important determined parameter was the vitamin E/cholesterol ratio in serum and lipoproteins. The results indicate that both extracorporeal elimination methods are effective and suitable ways to treat severe familial hypercholesterolemia, as the LDL fraction of cholesterol decreased by approximately 77% and 66% following LDL-apheresis and rheohaemapheresis, respectively. In addition, the serum vitamin E decreased by 54% and 57% and the decrease of the serum vitamin A was approximately 20%. However, the main marker of antioxidant capacity, vitamin E/cholesterol ratio, in the serum, VLDL and LDL significantly increased. The increase of vitamin E levels in the erythrocyte membranes of 2% following LDL-apheresis and a significant increase of 4% following rheohaemapheresis were confirmed. The presented results indicate that LDL-apheresis and rheohaemapheresis can be considered to be safe procedures according to the antioxidant capacity of the serum, VLDL and LDL lipoprotein fractions and the erythrocyte membrane. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2016
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