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Selected Ga-68-siderophores versus Ga-68-colloid and Ga-68-citrate: biodistribution and small animal imaging in mice
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SYSNO ASEP 0446378 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Selected Ga-68-siderophores versus Ga-68-colloid and Ga-68-citrate: biodistribution and small animal imaging in mice Author(s) Petřík, M. (CZ)
Vlčková, A. (CZ)
Nový, Z. (CZ)
Urbánek, Lubor (UEB-Q) RID
Haas, H. (AT)
Decristoforo, C. (AT)Source Title Biomedical Papers. - : Univerzita Palackého v Olomouci - ISSN 1213-8118
Roč. 159, č. 1 (2015), s. 60-66Number of pages 7 s. Language eng - English Country CZ - Czech Republic Keywords gallium-68 ; siderophores ; colloid Subject RIV EB - Genetics ; Molecular Biology R&D Projects LO1304 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEB-Q - RVO:61389030 UT WOS 000351716500010 DOI 10.5507/bp.2014.052 Annotation Background. Ga-68-triacetylfusarinine C (TAFC) and Ga-68-ferrioxamine E (FOXE) show great potential to be used as highly sensitive and selective tracers for Aspergillus infection imaging. Here we report on a comparison of the ex vivo biodistribution and small animal imaging of Ga-68-TAFC and Ga-68-FOXE versus Ga-68-colloid and Ga-68-citrate as unspecific control in mice. Methods. The radiochemical purity of tested Ga-68 labelled tracers was determined by RP-HPLC or ITLC-SG. Ex vivo biodistribution was studied in normal DBA/2 mice 30 min and 90 min p.i_ Static and dynamic imaging were performed using mu PET/CT. Results. Ga-68-TAFC and Ga-68-FOXE showed rapid renal excretion and low blood values even 90 min p.i_ Ga-68-TAFC showed almost no retention in other organs while 68Ga-FOXE displayed some uptake in gastrointestinal tract. Ga-68-colloid and Ga-68-citrate revealed significantly different ex vivo biodistribution. Ga-68-colloid showed pronounced radioactivity retention in the liver, while Ga-68-citrate displayed high blood values and significant retention of radioactivity in highly perfused organs. Conclusions. From the results, both Ga-68-TAFC and Ga-68-FOXE have excellent and significantly different in vivo behaviour compared to Ga-68-colloid and Ga-68-citrate. Ga-68-TAFC in particular confirmed its great potential use as a specific tracer for Aspergillus infection imaging. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2016
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