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Seasonal pharmacological properties and alkaloid content in Cyrtanthus contractus NE Br
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SYSNO ASEP 0446274 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Seasonal pharmacological properties and alkaloid content in Cyrtanthus contractus NE Br Author(s) Ncube, B. (ZA)
Nair, J. J. (ZA)
Rárová, Lucie (UEB-Q) RID, ORCID
Strnad, Miroslav (UEB-Q) RID, ORCID
Finnie, J.F. (ZA)
van Staden, J. (ZA)Source Title South African Journal of Botany. - : Elsevier - ISSN 0254-6299
Roč. 97, MAR 2015 (2015), s. 69-76Number of pages 8 s. Language eng - English Country ZA - South Africa Keywords Acetylcholinesterase ; Alkaloids ; Cyrtanthus Subject RIV EB - Genetics ; Molecular Biology R&D Projects LO1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEB-Q - RVO:61389030 UT WOS 000350654800009 DOI 10.1016/j.sajb.2014.12.005 Annotation Representatives of the genus Cyrtanthus including Cyrtanthus contractus of the Amaryllidaceae family are widely used in African traditional medicine for the treatment of a range of ailments, including mental illness and age-related dementia. The alkaloid constituents distributed within the genus, which are chiefly responsible for the biological activity of the derived extracts, are thought to be influenced by changes in the growing environment. Natural growing populations of C. contractus were tagged and collected every 15th day of each month over a 12 month period. The ethanol bulb extracts from each of the collected samples were evaluated for total alkaloid content, cytotoxic effects, acetylcholinesterase and cyclooxygenase inhibition as well as antimicrobial activities. Some notable bioactivities were recorded for extracts collected during certain months of the year, particularly the cytotoxic effects against human cancer cell lines and enzyme inhibition (AChE and COX). The cytotoxic effects and AChE and COX enzyme inhibitory activities of extracts collected in May and September are of considerable interest. Similarly total alkaloids varied markedly from one month to the other. The bioactivity exhibited by C. contractus bulb extracts during certain months of the year, particularly in May and September, justifies the collection and use of these bulbs for treatment of the relevant ailments in traditional medicine during these periods. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2016
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