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Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters

SYSNO ASEP	0435165
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters
Author(s)	Hofer, Michal (BFU-R)_{RID, ORCID} Pospíšil, Milan (BFU-R) Dušek, L. (CZ) Hoferová, Zuzana (BFU-R)_RID Komůrková, Denisa (BFU-R)_{RID, ORCID}
Number of authors	5
Source Title	Purinergic Signalling - ISSN 1573-9538 Roč. 10, č. 3 (2014), s. 509-514
Number of pages	6 s.
Publication form	Print - P
Language	eng - English
Country	NL - Netherlands
Keywords	Adenosine A(3) receptor ; Adenosine A(3) receptor knockout mice ; Hematopoiesis
Subject RIV	BO - Biophysics
R&D Projects	GAP303/11/0128 GA ČR - Czech Science Foundation (CSF)
Institutional support	BFU-R - RVO:68081707
UT WOS	000341772500010
DOI	10.1007/s11302-014-9412-9
Annotation	The role of the adenosine A(3) receptor in hematopoiesis was studied using adenosine A(3) receptor knockout (A(3)AR KO) mice. Hematological parameters of peripheral blood and femoral bone marrow of irradiated and untreated A(3)AR KO mice and their wild-type (WT) counterparts were investigated. Irradiation of the mice served as a defined hematopoiesis-damaging means enabling us to evaluate contingent differences in the pattern of experimentally induced hematopoietic suppression between the A(3)AR KO mice and WT mice. Defects were observed in the counts and/or functional parameters of blood cells in the A(3)AR KO mice. These defects include statistically significantly lower values of blood neutrophil and monocyte counts, as well as those of mean erythrocyte volume, mean erythrocyte hemoglobin, blood platelet counts, mean platelet volume, and plateletcrit, and can be considered to bear evidence of the lack of a positive role played by the adenosine A(3) receptor in the hematopoietic system.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2015

Number of the records: 1