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Essential oil from Myrica rubra leaves inhibits cancer cell proliferation and induces apoptosis in several human intestinal lines

SYSNO ASEP	0432566
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Essential oil from Myrica rubra leaves inhibits cancer cell proliferation and induces apoptosis in several human intestinal lines
Author(s)	Langhansová, Lenka (UEB-Q)_{RID, ORCID} Hanusová, V. (CZ) Rezek, Jan (UEB-Q)_{RID, ORCID} Stohanslová, B. (CZ) Ambrož, M. (CZ) Králová, V. (CZ) Vaněk, Tomáš (UEB-Q)_{RID, ORCID} Lou, J.D. (CN) Yun, Z.L. (CN) Yang, J. (CN) Skálová, L. (CZ)
Source Title	Industrial Crops and Products. - : Elsevier - ISSN 0926-6690 Roč. 59, AUG 2014 (2014), s. 20-26
Number of pages	7 s.
Language	eng - English
Country	NL - Netherlands
Keywords	Myrica rubra ; Essential oil ; Antiproliferative effect
Subject RIV	FR - Pharmacology ; Medidal Chemistry
R&D Projects	LH12165 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UEB-Q - RVO:61389030
UT WOS	000339600400004
DOI	10.1016/j.indcrop.2014.04.018
Annotation	The leaves of Myrica rubra (Sieb. et Zucc), a subtropical Asian fruit tree with traditional use in folk medicines, were extracted by hydrodistillation. The antiproliferative effect of obtained M. rubra essential oil (MEO) was tested in human colon and ileocecal adenocarcinoma cell lines HCT8, SW620, SW480, HT29 and Caco2. Cytostatic drug paclitaxel was used as a positive control. MEO significantly inhibited cell proliferation in concentration-dependant manner in all cell lines. The efficacy of ME differed in individual cell lines, with Caco2 being the most sensitive. In these cells, MEO, IC50 value of 1.5 mu g/mL was obtained using xCelligence system for real-time cell monitoring. In cancer cells, MEC) induces apoptosis and caused significant increase of activities of initiator as well as effector caspases. Contrary to cancer cells, MEC) did not affect viability of isolated hepatocytes (as a model of normal non-cancerous cells). GC x GC-TOFMS analysis of MEC, chemical composition revealed beta-caryophyllene, alpha-humulene, humulene epoxide I, valencene, epi-alpha-selinene, gamma-muurolene, beta-caryphyllene-oxide, and trans-nerolidol as dominant compounds.
Workplace	Institute of Experimental Botany
Contact	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Year of Publishing	2015

Number of the records: 1