Copper-mediated Synthesis of Mono- and Dichlorinated Diaryl Ethers

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SYSNO ASEP	0429530
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Copper-mediated Synthesis of Mono- and Dichlorinated Diaryl Ethers
Author(s)	Čermák, Jan K. (UCHP-M)_{RID, SAI} Církva, Vladimír (UCHP-M)_{RID, ORCID, SAI}
Source Title	Tetrahedron Letters. - : Elsevier - ISSN 0040-4039 Roč. 55, č. 30 (2014), s. 4185-4188
Number of pages	4 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	O-arylation ; Chan-Lam coupling ; kovats indices
Subject RIV	CC - Organic Chemistry
Institutional support	UCHP-M - RVO:67985858
UT WOS	000339128700039
DOI	10.1016/j.tetlet.2014.06.035
Annotation	An efficient synthesis of polychlorinated diphenyl ethers (PCDEs) using the Cu(OAc)2 catalyzed Chan–Lam coupling reaction is described. A library of all possible mono- and dichlorinated diphenyl ether congeners was prepared and characterized using MS, 1H, and 13C NMR spectroscopy, and Kovats retention indices. Our approach, using the optimized reaction conditions (i.e., reaction temperature, oxidizing atmosphere and base), significantly improves and simplifies the process compared to previously reported syntheses.
Workplace	Institute of Chemical Process Fundamentals
Contact	Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227
Year of Publishing	2015

Number of the records: 1