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X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids

SYSNO ASEP	0424947
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids
Author(s)	Bhattacharyya, Tanmoy (UMG-J) Reifová, R. (CZ) Gregorová, Soňa (UMG-J) Šimeček, Petr (UMG-J) Gergelits, Václav (UMG-J) Mistrik, M. (CZ) Martincová, Iva (UBO-W)_ORCID Piálek, Jaroslav (UBO-W)_{RID, ORCID, SAI} Forejt, Jiří (UMG-J)_{RID, ORCID}
Source Title	PLoS Genetics. - : Public Library of Science - ISSN 1553-7404 Roč. 10, č. 2 (2014), e1004088
Number of pages	15 s.
Language	eng - English
Country	US - United States
Keywords	hybrid sterility ; meiotic asynapsis ; chromosome substitution strains
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	Premium Academiae of the Academy of Sciences of the Czech Republic GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR)
	LD11079 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA206/08/0640 GA ČR - Czech Science Foundation (CSF)
	ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UBO-W - RVO:68081766 ; UMG-J - RVO:68378050
UT WOS	000332021500056
DOI	10.1371/journal.pgen.1004088
Annotation	Genomes of newly emerging species restrict their gene exchange with related taxa in order to secure integrity. Hybrid sterility is one of the reproductive isolation mechanisms restricting gene flow between closely related, sexually reproducing organisms. We showed that hybrid sterility between two closely related mouse subspecies is executed by a failure of meiotic synapsis of orthologous chromosomes in F1 hybrid males. The asynapsis of orthologous chromosomes occurred in meiosis of male and female hybrids, though only males were sterile due to trans-acting male-specific hybrid sterility genes. We located one of the two major hybrid sterility genes to a 4.7 Mb interval on Chromosome X, showed that it controls male sterility by modulating the extent of meiotic asynapsis and using the inter-subspecific chromosome substitution strains we refuted the simple interpretation of dominance theory of Haldane's rule. A new working hypothesis posits male sterility of mouse inter-subsubspecific F1 hybrids as a consequence of meiotic chromosome asynapsis caused by the cis-acting mismatch between orthologous chromosomes modulated by the trans-acting hybrid male sterility genes.
Workplace	Institute of Molecular Genetics
Contact	Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217
Year of Publishing	2014

Number of the records: 1