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Amides derived from heteroaromatic amines and selected steryl hemiesters
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SYSNO ASEP 0398419 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Amides derived from heteroaromatic amines and selected steryl hemiesters Author(s) Bildziukevich, Uladzimir (UEB-Q) RID, ORCID
Rárová, L. (CZ)
Šaman, David (UOCHB-X) RID, ORCID
Havlíček, Libor (UEB-Q) RID, ORCID
Drašar, P. (CZ)
Wimmer, Zdeněk (UEB-Q) RID, ORCIDSource Title Steroids. - : Elsevier - ISSN 0039-128X
Roč. 78, č. 14 (2013), s. 1347-1352Number of pages 6 s. Language eng - English Country US - United States Keywords Heteroaromatic amine ; Cholesterol ; Lanosterol Subject RIV FR - Pharmacology ; Medidal Chemistry R&D Projects GAP503/11/0616 GA ČR - Czech Science Foundation (CSF) Institutional support UEB-Q - RVO:61389030 ; UOCHB-X - RVO:61388963 UT WOS 000328303300006 DOI 10.1016/j.steroids.2013.10.003 Annotation The current interest of the team has been focused on investigation of novel amides with potential cytotoxicity. The presented series of compounds was synthesized from selected steryl hemiesters and heteroaromatic amines. The synthetic protocol was designed in a simple and economic way, and divided into several general methodologies applicable to the compounds synthesized. The cytotoxicity was tested on cells derived from human T-lymphoblastic leukemia, breast adenocarcinoma and cervical cancer, and compared with tests on normal human fibroblasts. Most of the lanosterol-based compounds (3–5 and 7–10) showed medium to good cytotoxicity, while only two derivatives of cholesterol (18 and 19) showed medium cytotoxicity on human T-lymphoblastic leukemia cell line. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2014
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