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Characterization of Rabensburg virus, a flavivirus closely related to West Nile virus of the Japanese encephalitis antigenic group
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SYSNO ASEP 0383763 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Characterization of Rabensburg virus, a flavivirus closely related to West Nile virus of the Japanese encephalitis antigenic group Author(s) Aliota, M. T. (US)
Jones, S. A. (US)
Dupuis, A. P. (US)
Ciota, A. T. (US)
Hubálek, Zdeněk (UBO-W) RID, SAI, ORCID
Kramer, L. D. (US)Number of authors 6 Source Title PLoS ONE. - : Public Library of Science - ISSN 1932-6203
Roč. 7, č. 6 (2012), e39387Number of pages 6 s. Publication form Online - E Language eng - English Country US - United States Keywords Insect-specific flaviviruses ; Northeastern United-States ; Culex pipiens Subject RIV EE - Microbiology, Virology Institutional support UBO-W - RVO:68081766 UT WOS 000305652700075 EID SCOPUS 84862526803 DOI 10.1371/journal.pone.0039387 Annotation Rabensburg virus (RABV), a Flavivirus with similar to 76% nucleotide and 90% amino acid identity with representative members of lineage one and two West Nile virus (WNV), previously was isolated from Culex pipiens and Aedes rossicus mosquitoes in the Czech Republic, and phylogenetic and serologic analyses demonstrated that it was likely a new lineage of WNV. However, no direct link between RABV and human disease has been definitively established and the extent to which RABV utilizes the typical WNV transmission cycle is unknown. Herein, we evaluated vector competence and capacity for vertical transmission (VT) in Cx. pipiens; in vitro growth on avian, mammalian, and mosquito cells; and infectivity and viremia production in birds. RABV infection and replication only were detected on mosquito cells. Experimentally inoculated birds did not become infected. Cx. pipiens had poor peroral vector competence and a higher VT rate as compared to US-WNV in Cx. pipiens. As a result, we postulate that RABV is an intermediate between the mosquito-specific and horizontally transmitted flaviviruses. Workplace Institute of Vertebrate Biology Contact Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Year of Publishing 2013
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