Number of the records: 1  

GMI1, a structural-maintenance-of-chromosomes-hinge domain-containing protein, is involved in somatic homologous recombination in Arabidopsis

  1. 1.
    SYSNO ASEP0365270
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleGMI1, a structural-maintenance-of-chromosomes-hinge domain-containing protein, is involved in somatic homologous recombination in Arabidopsis
    Author(s) Bohmdorfer, G. (AT)
    Schleiffer, A. (AT)
    Brunmeir, R. (SG)
    Ferscha, S. (AT)
    Nizhynska, V. (AT)
    Kozák, Jaroslav (UEB-Q)
    Angelis, Karel (UEB-Q) RID, ORCID
    Kreil, D. P. (AT)
    Schweizer, D. (AT)
    Source TitlePlant Journal. - : Wiley - ISSN 0960-7412
    Roč. 67, č. 3 (2011), s. 420-433
    Number of pages14 s.
    Languageeng - English
    CountryGB - United Kingdom
    Keywordsstructural maintenance of chromosomes ; DNA repair ; somatic homologous recombination
    Subject RIVEI - Biotechnology ; Bionics
    R&D Projects1M0505 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    LC06004 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
    CEZAV0Z50380511 - UEB-Q (2005-2011)
    UT WOS000293176600004
    DOI10.1111/j.1365-313X.2011.04604.x
    AnnotationDNA double-strand breaks (DSBs) pose one of the most severe threats to genome integrity, potentially leading to cell death. After detection of a DSB, the DNA damage and repair response is initiated and the DSB is repaired by non-homologous end joining and/or homologous recombination. Many components of these processes are still unknown in Arabidopsis thaliana. In this work, we characterized gamma-irradiation and mitomycin C induced 1 (GMI1), a member of the SMC-hinge domain-containing protein family. RT-PCR analysis and promoter-GUS fusion studies showed that gamma-irradiation, the radio-mimetic drug bleocin, and the DNA cross-linking agent mitomycin C strongly enhance GMI1 expression particularly in meristematic tissues. The induction of GMI1 by gamma-irradiation depends on the signalling kinase Ataxia telangiectasia-mutated (ATM) but not on ATM and Rad3-related (ATR).
    WorkplaceInstitute of Experimental Botany
    ContactDavid Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
    Year of Publishing2012
Number of the records: 1  

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