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Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor
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SYSNO ASEP 0364584 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Shh Expression in a Rudimentary Tooth Offers New Insights Into Development of the Mouse Incisor Author(s) Hovořáková, Mária (UEM-P) RID
Procházka, Jan (UEM-P)
Lesot, H. (FR)
Smrčková, Lucie (UEM-P)
Churavá, Svatava (UEM-P)
Boráň, T. (CZ)
Kozmik, Zbyněk (UMG-J) RID
Klein, O. (US)
Peterková, Renata (UEM-P) RID
Peterka, Miroslav (UEM-P) RIDSource Title Journal of Experimental Zoology Part B: Molecular and Developmental Evolution Additional Title Information. - : Wiley - ISSN 1552-5007
346B, č. 5 (2011), s. 347-358Number of pages 12 s. Language eng - English Country US - United States Keywords morphogenesis ; human embryos ; deciduous dentition Subject RIV EA - Cell Biology R&D Projects GA304/07/0223 GA ČR - Czech Science Foundation (CSF) GA304/09/1579 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50390512 - UEM-P (2005-2011) AV0Z50520514 - UMG-J (2005-2011) UT WOS 000291699400005 EID SCOPUS 79958773694 DOI 10.1002/jez.b.21408 Annotation Using a combination of histology, 3D reconstructions and Shh whole mount in situ hybridization (WISH) analyses, several Sonic hedgehog (Shh) expression domains have been shown sequentially appearing in the lower WT mouse incisor region during early development. In contrast to the single Shh expression domain that is widely assumed to be present in each lower incisor area at ED12.5-13.5, two spatially distinct regions of Shh expression have been identified that appeared in an anterior-posterior sequence during this period. The initial anterior, more superficially located Shh expression region represented the rudimentary (so-called deciduous) incisor, whereas only the later posterior deeper situated region corresponded to the prospective functional incisor. These findings strongly suggest the necessity to re-interpret previous results based on either morphology alone or on the detection of signaling molecules alone, and offer a new insight into the interpretation of existing data from mutant mice. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2012
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