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Bone marrow dendritic cell-based anticancer vaccines
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SYSNO ASEP 0191425 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Bone marrow dendritic cell-based anticancer vaccines Author(s) Indrová, Marie (UMG-J) RID
Mendoza, Luis (UMG-J)
Reiniš, Milan (UMG-J) RID
Vonka, V. (CZ)
Šmahel, M. (CZ)
Němečková, Š. (CZ)
Jandlová, Táňa (UMG-J)
Bubeník, Jan (UMG-J)Source Title Advances in Experimental Medicine and Biology - ISSN 0065-2598
Roč. 495, - (2001), s. 355-358Number of pages 4 s. Language eng - English Country US - United States Keywords HPV16 ; dendritic cells ; tumour vaccines Subject RIV EB - Genetics ; Molecular Biology R&D Projects NC5526 GA MZd - Ministry of Health (MZ) GA312/98/0826 GA ČR - Czech Science Foundation (CSF) GA312/99/0542 GA ČR - Czech Science Foundation (CSF) GA301/00/0114 GA ČR - Czech Science Foundation (CSF) GA301/01/0985 GA ČR - Czech Science Foundation (CSF) IAA7052002 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z5052915 - UMG-J Annotation Murine carcinoma MK16 was utilized to compare the efficacz of loading dendritic cells with tumour lysates and a synthetic HPV16 E7-derived peptide. It has been found that loading the DC with tumour lysate is more efficient for .I.in vitro priming of syngeneic spleen cells than loading with the immunodominant peptide and that two established DC lines are also able to prime the mitogenic activity of syngeneic spleen cells after loading with antigen. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2002
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