Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2
1.
SYSNO ASEP
0173739
Document Type
J - Journal Article
R&D Document Type
Journal Article
Subsidiary J
Ostatní články
Title
Lipoxygenease inhibitors enhance tumor suppressive effects of Jun proteins on v-myb-transformed monoblasts BM2
Author(s)
Bryja, Vítězslav (UEM-P) Sedláček, J. (CZ) Zahradníčková, E. (CZ) Ševčíková, S. (CZ) Pacherník, J. (CZ) Souček, K. (CZ) Hofmanová, J. (CZ) Kozubík, A. (CZ) Šmarda, J. (CZ)
Source Title
Prostaglandins & Other Lipid Mediators. - : Elsevier
- ISSN 1098-8823
Roč. 72, - (2003), s. 131-145
Number of pages
15 s.
Language
eng - English
Country
US - United States
Keywords
hematopoiesis
Subject RIV
EB - Genetics ; Molecular Biology
R&D Projects
GA301/01/0040 GA ČR - Czech Science Foundation (CSF)
GA524/03/0766 GA ČR - Czech Science Foundation (CSF)
CEZ
AV0Z5039906 - UEM-P
MSM 14300008
Annotation
In this study lipoxygenase inhibitors were used to study the role of arachidonic acid metabolism in regulation of proliferation and apoptosis of chicken monoblasts BM2 and its functional interaction with Jun proteins. It was demonstrated that lipoxygenase inhibitors further enforce tumor suppresive capabilities of Jun proteins by inducing either more efficient cell cycle block and/or apoptosis in BM2 cells. This suggests that there is a crosstalk between the lipoxygenase- and Jun-directed pathways in regulation of proliferation and differentiation of leukemic cells.
