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Lipoxygenase inhibitors enhance tumor suppressive effects of Jun proteins v-myb-transformed monoblasts BM2
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SYSNO ASEP 0127049 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Lipoxygenase inhibitors enhance tumor suppressive effects of Jun proteins v-myb-transformed monoblasts BM2 Author(s) Bryja, V. (CZ)
Sedláček, J. (CZ)
Zahradníčková, E. (CZ)
Ševčíková, S. (CZ)
Pacherník, Jiří (BFU-R)
Souček, Karel (BFU-R) RID, ORCID
Hofmanová, Jiřina (BFU-R) RID, ORCID
Kozubík, Alois (BFU-R) RID, ORCID
Šmarda, J. (CZ)Source Title Prostaglandins - ISSN 0090-6980
Roč. 72, 3-4 (2003), s. 131-145Number of pages 15 s. Language eng - English Country US - United States Keywords hematopoiesis ; arachidonic acid ; lipoxygenase inhibitors Subject RIV BO - Biophysics R&D Projects GA301/01/0040 GA ČR - Czech Science Foundation (CSF) GA524/03/0766 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z5004920 - BFU-R Annotation Inhibitors of arachidonic acid (AA) conversion were described as suppressors of proliferation and inducers of differentiation of various leukemic cells. Certain AA metabolites have been shown to cooperate with Jun proteins that are important factors controlling cell proliferation, differentiation and apoptosis. Using lipoxygenase (LOX) inhibitors of various specifity we studied possible participation of lipoxygenase pathway in regulation of proliferation and apoptosis of v-myb-transformed chicken monoblasts BM2 and its functional interaction with Jun proteins. We found that nordihydroguaiaretic acid (NDGA) and esculetin (Esc) negatively regulate proliferation of BM2 cells causing accumulation in either G(0)/G(1)-phase (nordihydroguaiaretic acid) or S-phase (esculetin) of the cell cycle. BM2 cells can be also induced to undergo growth arrest and partial differentiation by ectopic expression of Jun proteins. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2004
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