Number of the records: 1
The role of NK1.1+ cells in the protection against MHC class I+ HPV16-associated tumours
- 1.
SYSNO ASEP 0108993 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title The role of NK1.1+ cells in the protection against MHC class I+ HPV16-associated tumours Title Úloha buněk NK1.1+ v ochraně proti MHC I+ nádorům vyvolaným HPV16 Author(s) Šímová, Jana (UMG-J) RID
Bubeník, Jan (UMG-J)
Bieblová, Jana (UMG-J)
Jandlová, Táňa (UMG-J)Source Title Folia Biologica. - : Univerzita Karlova v Praze - ISSN 0015-5500
Roč. 50, č. 6 (2004), s. 200-202Number of pages 3 s. Language eng - English Country CZ - Czech Republic Keywords HPV16 ; MHC class I expression ; NK1.1+ cells Subject RIV EC - Immunology R&D Projects IAA5052203 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KSK5011112 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) NC7148 GA MZd - Ministry of Health (MZ) NR7807 GA MZd - Ministry of Health (MZ) CEZ AV0Z5052915 - UMG-J Annotation Depletion of NK1.1+ cells by repeated i.p. injections of PK136 antibody significantly enhanced growth of MHC class I+ tumours in syngeneic mice. Depletion starting before tumour transplantation substantially accelerated tumour growth; depletion starting on day 7 or 14 after tumour transplantation was without any effect. These results indicate that the NK1.1+ cells play an important inhibitory role during the early phase of the growth of some MHC class I+ tumours. Since the relevant target for NK cells is a \"missing self\" signal, absence of the MHC class I molecules, the NK cells cannot be expected to directly inhibit the growth of the MHC class I+ tumours. The results indicate that the effects of non-NK cells or indirect effects mediated by NK cell interactions and release of cytokines were responsible for the results Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2005
Number of the records: 1