Number of the records: 1
Effects of stable adenosine receptor agonists on bone marrow haematopoietic cells as inferred from the cytotoxic action of 5-fluorouracil
- 1.
SYSNO ASEP 0104659 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Effects of stable adenosine receptor agonists on bone marrow haematopoietic cells as inferred from the cytotoxic action of 5-fluorouracil Title Účinky stabilních agonistů adenosinových receptorů na krvetvorné buňky kostní dřeně poškozené cytotoxickým působením 5-fluorouracilu Author(s) Pospíšil, Milan (BFU-R)
Hofer, Michal (BFU-R) RID, ORCID
Vacek, Antonín (BFU-R)
Znojil, V. (CZ)
Pipalová, I. (CZ)Source Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 53, č. 3 (2004), s. 549-556Number of pages 8 s. Language eng - English Country CZ - Czech Republic Keywords adenosine receptor agonists ; hematopoiesis ; 5-fluorouracil Subject RIV BO - Biophysics R&D Projects GA305/02/0423 GA ČR - Czech Science Foundation (CSF) IBS5004009 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) KSK5011112 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z5004920 - BFU-R Annotation The aim of the study was to investigate the effects of stable adenosine receptor agonists on bone marrow hematopoiesis by utilizing the model of hematopoietic damage induced by 5-fluorouracil (5-FU), a cycle-specific cytotoxic agent. Effects of a non-selective agonist NECA activating all the known adenosine receptors (A(1), A(2A), A(2B), A(3)) and of the selective agonists for A(1) (CPA), A(2A) (CGS 21680), and A(3) (IB-MECA) adenosine receptors were investigated. Experiments were performed with B10CBAF1 mice under in vivo conditions. Adenosine receptor agonists were given in single injections before 5-FU administration and the effects were determined 4 days later. The numbers of femoral marrow nucleated cells and hematopoietic progenitor cells (CFC-GM and BFU-E) were taken as indices of the effects. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2005
Number of the records: 1