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Immunization with MHC class I-negative but not -positive HPV16-associated tumour cells inhibits growth of MHC class I-negative tumours
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SYSNO ASEP 0092897 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Immunization with MHC class I-negative but not -positive HPV16-associated tumour cells inhibits growth of MHC class I-negative tumours Title Imunizace MHC I negativními nádorovými buňkami, ale nikoliv pozitivními, asociovanými s HPV16 inhibovala růst MHC I negativních asociovaných s HPV16 Author(s) Reiniš, Milan (UMG-J) RID
Šímová, Jana (UMG-J) RID
Indrová, Marie (UMG-J) RID
Bieblová, Jana (UMG-J)
Přibylová, Hana (UMG-J)
Moravcová, Simona (UMG-J) RID
Jandlová, Táňa (UMG-J)
Bubeník, Jan (UMG-J)Source Title International Journal of Oncology. - : Spandidos Publications - ISSN 1019-6439
Roč. 30, č. 4 (2007), s. 1011-1017Number of pages 7 s. Language eng - English Country GR - Greece Keywords HPV16 ; MHC class I-deficient tumours ; immunologic crossreaction Subject RIV EB - Genetics ; Molecular Biology R&D Projects NR7807 GA MZd - Ministry of Health (MZ) CEZ AV0Z50520514 - UMG-J (2005-2011) Annotation Loss or downregulation of MHC class I molecules on tumour cells is a common mechanism by which tumours can escape from T-cell mediated immune responses. In this study we have investigated the immunologic crossreactivity between murine tumour cell lines expressing human papilloma virus (HPV) 16-derived E6/E7 oncoproteins with distinct surface expression of MHC class I molecules. Our data showed that immunization with MHC class I-deficient but not with MHC class I positive tumour cells inhibited the growth of MHC class I-deficient tumours. In vivo depletion studies revealed that the mechanisms underlying effective immune responses against MHC class I-negative tumours in animals immunized with MHC class I-deficient tumour cells involved natural killer cells. The presented findings are of particular clinical relevance in the sense of construction of vaccines directed against a broad spectrum of HPV-associated tumours. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2008
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