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Adenosine A3 receptor agonist acts as a homeostatic regulator of bone marrow hematopoiesis
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SYSNO ASEP 0085339 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Adenosine A3 receptor agonist acts as a homeostatic regulator of bone marrow hematopoiesis Title Agonista adenosinového receptoru A3 funguje jako homeostatický regulátor krvetvorby v kostní dřeni Author(s) Hofer, Michal (BFU-R) RID, ORCID
Pospíšil, Milan (BFU-R)
Znojil, V. (CZ)
Holá, Jiřina (BFU-R)
Vacek, Antonín (BFU-R)
Štreitová, Denisa (BFU-R)Source Title Biomedicine & Pharmacotherapy. - : Elsevier - ISSN 0753-3322
Roč. 61, č. 6 (2007), s. 356-359Number of pages 4 s. Language eng - English Country FR - France Keywords adenosine A3 receptor ; cell proliferation ; hematopoiesis Subject RIV BO - Biophysics R&D Projects GA305/06/0015 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50040507 - BFU-R (2005-2011) AV0Z50040702 - BFU-R (2007-2013) Annotation Effects of 2-day therapy with the adenosine A3 receptor agonist, IB-MECA, on proliferation state of the granulopoietic and erythropoietic compartments of mouse bone marrow were investigated. Significant negative correlation between the control proliferation state and the increase of cell proliferation after IB-MECA treatment was found. These results suggest the homeostatic character of the induced stimulatory effects and the need to respect the functional state of the target tissue when investigating effects of adenosine receptor agonists under in vivo conditions. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2008
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