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The role of G-CSF and IL-6 in the granulopoiesis-stimulating activity of murine blood serum induced by perorally administered ultrafiltered pig leukocyte extract, IMUNOR

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    SYSNO ASEP0080840
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JOstatní články
    TitleThe role of G-CSF and IL-6 in the granulopoiesis-stimulating activity of murine blood serum induced by perorally administered ultrafiltered pig leukocyte extract, IMUNOR
    TitleÚloha G-CSF a IL-6 v granulopoézu stimulující aktivitě myšího krevního séra, indukované perorálně podaným ultrafiltrovaným extraktem prasečích leukocytů, IMUNORem
    Author(s) Vacek, Antonín (BFU-R)
    Hofer, Michal (BFU-R) RID
    Holá, Jiřina (BFU-R)
    Weiterová, Lenka (BFU-R) RID
    Štreitová, Denisa (BFU-R)
    Svoboda, J. (CR)
    Source TitleInternational Immunopharmacology. - : Elsevier - ISSN 1567-5769
    Roč. 7, č. 5 (2007), s. 656-661
    Number of pages6 s.
    Languageeng - English
    CountryUS - United States
    KeywordsIMUNOR ; hematopoiesis ; cytokines
    Subject RIVBO - Biophysics
    CEZAV0Z50040702 - BFU-R (2007-2013)
    AnnotationWe have shown that hematopoiesis-stimulating activity of perorally administered low-molecular-weight (<12 kDa) extract of pig blood leukocytes, IMUNOR, is mediated by induction of production of granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6), whose elevated levels in sera after IMUNOR administration have been determined. Experiments using antibodies against the cytokines mentioned have demonstrated that G-CSF plays a key role in the stimulation of hematopoiesis by IMUNOR, whereas IL-6 has an auxiliary role.
    WorkplaceInstitute of Biophysics
    ContactJana Poláková, polakova@ibp.cz, Tel.: 541 517 244
    Year of Publishing2007
Number of the records: 1