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Depletion of Treg cells inhibits minimal residual disease after surgery of HPV16-associated tumours
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SYSNO ASEP 0044812 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Depletion of Treg cells inhibits minimal residual disease after surgery of HPV16-associated tumours Title Deplece regulačních T buněk potlačuje minimálni zbytkovou chorobu po chirurgickém odstranění nádorů asociovaných s HPV16 Author(s) Šímová, Jana (UMG-J) RID
Bubeník, Jan (UMG-J)
Bieblová, Jana (UMG-J)
Rosalia, Rodney Alexander (UMG-J)
Frič, Jan (UMG-J)
Reiniš, Milan (UMG-J) RIDSource Title International Journal of Oncology. - : Spandidos Publications - ISSN 1019-6439
Roč. 29, č. 6 (2006), s. 1567-1571Number of pages 5 s. Language eng - English Country GR - Greece Keywords HPV16 ; residual tumour disease ; Treg cells Subject RIV EB - Genetics ; Molecular Biology R&D Projects GA301/04/0492 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z50520514 - UMG-J (2005-2011) Annotation It is generally accepted that T regulatory cells (Treg CD4+CD25+Foxp3+) play an important role in the suppression of tumour immunity. We examined the impact of Treg cell depletion with anti-CD25 antibody as adjuvant therapy in the treatment of minimal residual disease after excision of murine HPV16-associated tumours. We found that the depletion of Treg cells inhibited growth of the recurrences after surgery of HPV16-associated MHC class I+ as well as MHC class I-deficient tumours transplanted in syngeneic mice. These results demonstrate that depletion of CD25+CD4+ Treg cells can be used as an efficient adjuvant treatment improving the results of surgery in the experimental systems mimicking human MHC class I+ and MHC class I-deficient, HPV16-associated neoplasms. Therefore, this therapeutic modality is worth being examined in patients with minimal residual HPV16-associated tumour disease after surgery. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2007
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