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Peroral IMUNOR, a low-molecular-weight immunomodulator prepared from disintegrated and ultrafiltered leukocytes, enhances recovery from myelosuppression induced by cisplatin or 5-fluorouracil
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SYSNO ASEP 0038982 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Peroral IMUNOR, a low-molecular-weight immunomodulator prepared from disintegrated and ultrafiltered leukocytes, enhances recovery from myelosuppression induced by cisplatin or 5-fluorouracil Title Perorální IMUNOR, imunomodulátor s nízkou molekulární hmotností připravený z desintegrovaných a ultrafiltrovaných leukocytů, posiluje úpravu útlumu kostní dřeně indukovaného cisplatinou nebo 5-fluorouracilem Author(s) Hofer, Michal (BFU-R) RID, ORCID
Vacek, Antonín (BFU-R)
Holá, Jiřina (BFU-R)
Weiterová, Lenka (BFU-R) RID
Štreitová, Denisa (BFU-R)Source Title Immunopharmacology and Immunotoxicology - ISSN 0892-3973
Roč. 28, č. 1 (2006), s. 1-11Number of pages 11 s. Language eng - English Country US - United States Keywords hematopoiesis ; myelosuppression ; immunomodulator Subject RIV BO - Biophysics R&D Projects KSK5011112 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) CEZ AV0Z50040507 - BFU-R (2005-2011) Annotation A single dose of IMUNOR, a low-molecular-weight immunomodulator prepared from disintegrated and ultrafiltered pig leukocytes, was found to enhance recovery of murine pool of hemopoietic progenitor cells for granulocytes and macrophages damaged by a single injection of cytotoxic drugs 5-fluorouracil or cisplatin. The best results were obtained after the treatment with IMUNOR on days 3 or 4 after the injection of 5-fluorouracil or cisplatin. These results together with previous findings obtained in our laboratory suggest that IMUNOR has the potential to become a part of treatment schemes in oncological practice aimed at alleviation of myelosuppression evoked by cytotoxic anti-tumor therapy. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2007
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