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Mechanical regulation of mitochondrial dynamics and function in a 3D-engineered liver tumor microenvironment
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SYSNO ASEP 0572095 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mechanical regulation of mitochondrial dynamics and function in a 3D-engineered liver tumor microenvironment Author(s) Frtús, Adam (FZU-D) ORCID
Smolková, Barbora (FZU-D) ORCID
Uzhytchak, Mariia (FZU-D) ORCID
Lunova, Mariia (FZU-D) ORCID
Jirsa, M. (CZ)
Petrenko, Yuriy (UEM-P) RID, ORCID
Dejneka, Alexandr (FZU-D) RID, ORCID
Lunov, Oleg (FZU-D) ORCIDNumber of authors 8 Source Title ACS BIOMATERIALS SCIENCE & ENGINEERING. - : American Chemical Society - ISSN 2373-9878
Roč. 9, č. 5 (2023), s. 2408-2425Number of pages 18 s. Language eng - English Country US - United States Keywords engineered cell microenvironments ; cancer ; mitochondria ; mechanical forces ; extracellular matrix ; cytoskeleton ; cell plasticity Subject RIV BO - Biophysics OECD category Biophysics Subject RIV - cooperation Institute of Experimental Medicine - Biophysics R&D Projects GA22-18634S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support FZU-D - RVO:68378271 ; UEM-P - RVO:68378041 UT WOS 000972147400001 EID SCOPUS 85151914668 DOI 10.1021/acsbiomaterials.2c01518 Annotation It has become evident that physical stimuli of the cellular microenvironment transmit mechanical cues regulating key cellular functions, such as proliferation, migration, and malignant transformation. Accumulating evidence suggests that tumor cells face variable mechanical stimuli that may induce metabolic rewiring of tumor cells. We therefore designed soft 3D collagen scaffolds mimicking a pathological mechanical environment to decipher how liver tumor cells would adapt their metabolic activity to physical stimuli of the cellular microenvironment. Here, we report that the soft 3D microenvironment upregulates the glycolysis of HepG2 and Alexander cells. Both cell lines adapt their mitochondrial activity and function under growth in the soft 3D microenvironment. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2024 Electronic address https://hdl.handle.net/11104/0342923
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