Developmental Aspects of Cardiac Adaptation to Increased Workload

Ošťádal, Bohuslav; Kolář, František; Ošťádalová, Ivana; Sedmera, David; Olejníčková, Veronika; Hlaváčková, Markéta; Alánová, Petra

doi:https://dx.doi.org/10.3390/jcdd10050205

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Developmental Aspects of Cardiac Adaptation to Increased Workload

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SYSNO ASEP	0571996
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Developmental Aspects of Cardiac Adaptation to Increased Workload
Author(s)	Ošťádal, Bohuslav (FGU-C)_{RID, ORCID} Kolář, František (FGU-C)_{RID, ORCID, SAI} Ošťádalová, Ivana (FGU-C)_RID Sedmera, David (FGU-C)_{RID, ORCID, SAI} Olejníčková, Veronika (FGU-C)_{RID, ORCID, SAI} Hlaváčková, Markéta (FGU-C)_{RID, ORCID} Alánová, Petra (FGU-C)_{RID, ORCID}
Article number	205
Source Title	Journal of cardiovascular development and disease. - : MDPI Roč. 10, č. 5 (2023)
Number of pages	14 s.
Language	eng - English
Country	CH - Switzerland
Keywords	cardiac development ; adaptation to overload ; adaptive growth response ; phylogeny ; postnatal ontogeny ; hypertrophy ; hyperplasia
OECD category	Cardiac and Cardiovascular systems
R&D Projects	NU20J-02-00035 GA MZd - Ministry of Health (MZ)
	NU21J-02-00039 GA MZd - Ministry of Health (MZ)
	GJ19-04790Y GA ČR - Czech Science Foundation (CSF)
Method of publishing	Open access
Institutional support	FGU-C - RVO:67985823
UT WOS	000996922000001
EID SCOPUS	85160249589
DOI	10.3390/jcdd10050205
Annotation	The heart is capable of extensive adaptive growth in response to the demands of the body. When the heart is confronted with an increased workload over a prolonged period, it tends to cope with the situation by increasing its muscle mass. The adaptive growth response of the cardiac muscle changes significantly during phylogenetic and ontogenetic development. Cold-blooded animals maintain the ability for cardiomyocyte proliferation even in adults. On the other hand, the extent of proliferation during ontogenetic development in warm-blooded species shows significant temporal limitations: whereas fetal and neonatal cardiac myocytes express proliferative potential (hyperplasia), after birth proliferation declines and the heart grows almost exclusively by hypertrophy. It is, therefore, understandable that the regulation of the cardiac growth response to the increased workload also differs significantly during development. The pressure overload (aortic constriction) induced in animals before the switch from hyperplastic to hypertrophic growth leads to a specific type of left ventricular hypertrophy which, in contrast with the same stimulus applied in adulthood, is characterized by hyperplasia of cardiomyocytes, capillary angiogenesis and biogenesis of collagenous structures, proportional to the growth of myocytes. These studies suggest that timing may be of crucial importance in neonatal cardiac interventions in humans: early definitive repairs of selected congenital heart disease may be more beneficial for the long-term results of surgical treatment.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2024
Electronic address	https://www.mdpi.com/2308-3425/10/5/205

Number of the records: 1