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Evaluation of blood-brain barrier integrity by the analysis of dynamic contrast-enhanced MRI – a comparison of quantitative and semi-quantitative methods.
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SYSNO ASEP 0567451 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Evaluation of blood-brain barrier integrity by the analysis of dynamic contrast-enhanced MRI – a comparison of quantitative and semi-quantitative methods. Author(s) Kala, David (FGU-C)
Šulc, V. (CZ)
Olšerová, A. (CZ)
Svoboda, Jan (FGU-C)
Prysiazhniuk, Yeva (FGU-C) ORCID
Pošusta, Antonín (FGU-C) RID
Kynčl, M. (CZ)
Šanda, J. (CZ)
Tomek, A. (CZ)
Otáhal, Jakub (FGU-C) RID, ORCID, SAISource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 71, Suppl. 2 (2022), S259-s275Number of pages 17 s. Language eng - English Country CZ - Czech Republic Keywords DCE MRI ; time-intensity curve ; blood-brain barrier ; stroke ; Toft’s model OECD category Neurosciences (including psychophysiology R&D Projects NU21-08-00228 GA MZd - Ministry of Health (MZ) LM2018129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LX22NPO5107 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Research Infrastructure Czech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i. Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 000924861700011 EID SCOPUS 85146336279 DOI 10.33549/physiolres.934998 Annotation Disruption of the blood-brain barrier (BBB) is a key feature of various brain disorders. To assess its integrity a parametrization of dynamic magnetic resonance imaging (DCE MRI) with a contrast agent (CA) is broadly used. Parametrization can be done quantitatively or semi-quantitatively. Quantitative methods directly describe BBB permeability but exhibit several drawbacks such as high computation demands, reproducibility issues, or low robustness. Semi-quantitative methods are fast to compute, simply mathematically described, and robust, however, they do not describe the status of BBB directly but only as a variation of CA concentration in measured tissue. Our goal was to elucidate differences between five semi-quantitative parameters: maximal intensity (Imax), normalized permeability index (NPI), and difference in DCE values between three timepoints: baseline, 5 min, and 15 min (delta5-0, delta15-0, delta15-5) and two quantitative parameters: transfer constant (Ktrans) and an extravascular fraction (Ve). For the purpose of comparison, we analyzed DCE data of four patients 12-15 days after the stroke with visible CA enhancement. Calculated parameters showed abnormalities spatially corresponding with the ischemic lesion, however, findings in individual parameters morphometrically differed. Ktrans and Ve were highly correlated. Delta5-0 and delta15-0 were prominent in regions with rapid CA enhancement and highly correlated with Ktrans. Abnormalities in delta15-5 and NPI were more homogenous with less variable values, smoother borders, and less detail than Ktrans. Moreover, only delta15-5 and NPI were able to distinguish vessels from extravascular space. Our comparison provides important knowledge for understanding and interpreting parameters derived from DCE MRI by both quantitative and semi-quantitative methods. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2023 Electronic address https://www.biomed.cas.cz/physiolres/pdf/2022/71_S259.pdf
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