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Perineuronal nets affect memory and learning after synapse withdrawal
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SYSNO ASEP 0566603 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Perineuronal nets affect memory and learning after synapse withdrawal Author(s) Růžička, Jiří (UEM-P)
Dalecká, L. (CZ)
Šafránková, Kristýna (UEM-P)
Peretti, D. (GB)
Jendelová, Pavla (UEM-P) RID, ORCID
Kwok, Jessica (UEM-P) ORCID, RID
Fawcett, James (UEM-P) ORCIDArticle number 480 Source Title Translational Psychiatry . - : Springer - ISSN 2158-3188
Roč. 12, č. 1 (2022)Number of pages 13 s. Language eng - English Country US - United States Keywords conditioned place preference ; prefrontal cortex impairs ; extracellular-matrix ; chondroitin sulfate ; restores memory ; plasticity OECD category Neurosciences (including psychophysiology R&D Projects EF15_003/0000419 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA19-10365S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UEM-P - RVO:68378041 UT WOS 000884275600001 EID SCOPUS 85141821623 DOI 10.1038/s41398-022-02226-z Annotation Perineuronal nets (PNNs) enwrap mature neurons, playing a role in the control of plasticity and synapse dynamics. PNNs have been shown to have effects on memory formation, retention and extinction in a variety of animal models. It has been proposed that the cavities in PNNs, which contain synapses, can act as a memory store and that they remain stable after events that cause synaptic withdrawal such as anoxia or hibernation. We examine this idea by monitoring place memory before and after synaptic withdrawal caused by acute hibernation-like state (HLS). Animals lacking hippocampal PNNs due to enzymatic digestion by chondroitinase ABC or knockout of the PNN component aggrecan were compared with wild type controls. HLS-induced synapse withdrawal caused a memory deficit, but not to the level of untreated naive animals and not worsened by PNN attenuation. After HLS, only animals lacking PNNs showed memory restoration or relearning. Absence of PNNs affected the restoration of excitatory synapses on PNN-bearing neurons. The results support a role for hippocampal PNNs in learning, but not in long-term memory storage for correction of deficits. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2023 Electronic address https://www.nature.com/articles/s41398-022-02226-z
Number of the records: 1