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Myocardial m6A regulators in postnatal development: effect of sex

SYSNO ASEP	0565798
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Myocardial m6A regulators in postnatal development: effect of sex
Author(s)	Semenovykh, Dmytro (FGU-C)_ORCID Benák, Daniel (FGU-C) Holzerová, Kristýna (FGU-C)_{ORCID, RID} Černá, B. (CZ) Telenský, P. (CZ) Vavříková, Tereza (FGU-C) Kolář, František (FGU-C)_{RID, ORCID, SAI} Neckář, Jan (FGU-C)_{RID, ORCID} Hlaváčková, Markéta (FGU-C)_{RID, ORCID}
Source Title	Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408 Roč. 71, č. 6 (2022), s. 877-882
Number of pages	6 s.
Language	eng - English
Country	CZ - Czech Republic
Keywords	epitranscriptomics ; N6 -methyladenosine ; postnatal development ; heart
OECD category	Physiology (including cytology)
R&D Projects	GJ19-04790Y GA ČR - Czech Science Foundation (CSF)
Method of publishing	Open access
Institutional support	FGU-C - RVO:67985823
UT WOS	000908339300014
EID SCOPUS	85144635907
DOI	10.33549/physiolres.934970
Annotation	N6-methyladenosine (m6A) is an abundant mRNA modification affecting mRNA stability and protein expression. It is a highly dynamic process, and its outcomes during postnatal heart development are poorly understood. Here we studied m6A machinery in the left ventricular (LV) myocardium of Fisher344 male and female rats (postnatal days one to ninety, P1-P90) using Western Blot. A downward pattern of target protein levels (demethylases FTO and ALKBH5, methyltransferase METTL3, reader YTHDF2) was revealed in male and female rat LVs during postnatal development. On P1, the FTO protein level was significantly higher in male LVs compared to female.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2023
Electronic address	https://www.biomed.cas.cz/physiolres/pdf/2022/71_877.pdf

Number of the records: 1