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Myocardial development in crocodylians
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SYSNO ASEP 0565665 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Myocardial development in crocodylians Author(s) Kvasilová, A. (CZ)
Gregorovičová, Martina (FGU-C) RID, ORCID, SAI
Olejníčková, Veronika (FGU-C) RID, ORCID, SAI
Kolesová, Hana (FGU-C) RID, ORCID, SAI
Sedmera, David (FGU-C) RID, ORCID, SAISource Title Developmental Dynamics. - : Wiley - ISSN 1058-8388
Roč. 251, č. 12 (2022), s. 2029-2047Number of pages 19 s. Language eng - English Country US - United States Keywords cardiac conduction system ; crocodile embryo ; heart ; optical mapping ; septation ; vasculogenesis OECD category Developmental biology R&D Projects GA16-02972S GA ČR - Czech Science Foundation (CSF) LTC17023 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2015062 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support FGU-C - RVO:67985823 UT WOS 000853874800001 EID SCOPUS 85138082446 DOI 10.1002/dvdy.527 Annotation Background:Recent reports confirmed the notion that there exists a rudimentary cardiac conduction system (CCS) in the crocodylian heart, and development of its ventricular part is linked to septation. We thus analyzed myocardial development with the emphasis on the CCS components and vascularization in two different crocodylian species.Results:Using optical mapping and HNK-1 immunostaining, pacemaker activity was localized to the right-sided sinus venosus. The atrioventricular conduction was restricted to dorsal part of the atrioventricular canal. Within the ventricle, the impulse was propagated from base-to-apex initially by the trabeculae, later by the ventricular septum, in which strands of HNK-1 positivity were temporarily observed. Completion of ventricular septation correlated with transition of ventricular epicardial activation pattern to mature apex-to-base direction from two periapical foci. Despite a gradual thickening of the ventricular wall, no morphological differentiation of the Purkinje network was observed. Thin-walled coronary vessels with endothelium positive for QH1 obtained a smooth muscle coat after septation. Intramyocardial vessels were abundant especially in the rapidly thickening left ventricular wall.Conclusions:Most of the CCS components present in the homeiotherm hearts can be identified in the developing crocodylian heart, with a notable exception of the Purkinje network distinct from the trabeculae carneae. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2023 Electronic address https://doi.org/10.1002/dvdy.527
Number of the records: 1