Evaluation of linear versus star-like polymer anti-cancer nanomedicines in mouse models

Kostka, Libor; Kotrchová, Lenka; Randárová, Eva; Ferreira, C. A.; Malátová, Iva; Lee, H. J.; Olson, A. P.; Engle, J. W.; Kovář, Marek; Cai, W.; Šírová, Milada; Etrych, Tomáš

doi:https://dx.doi.org/10.1016/j.jconrel.2022.11.060

Number of the records: 1

Evaluation of linear versus star-like polymer anti-cancer nanomedicines in mouse models

1.

SYSNO ASEP	0565337
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Evaluation of linear versus star-like polymer anti-cancer nanomedicines in mouse models
Author(s)	Kostka, Libor (UMCH-V)_{RID, ORCID} Kotrchová, Lenka (UMCH-V)_{RID, ORCID} Randárová, Eva (UMCH-V)_RID Ferreira, C. A. (US) Malátová, Iva (MBU-M) Lee, H. J. (US) Olson, A. P. (US) Engle, J. W. (US) Kovář, Marek (MBU-M)_{RID, ORCID} Cai, W. (US) Šírová, Milada (MBU-M)_{RID, ORCID} Etrych, Tomáš (UMCH-V)_{RID, ORCID}
Source Title	Journal of Controlled Release. - : Elsevier - ISSN 0168-3659 Roč. 353, January (2023), s. 549-562
Number of pages	14 s.
Language	eng - English
Country	NL - Netherlands
Keywords	drug delivery ; cancer ; polymeric carriers
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
Subject RIV - cooperation	Institute of Microbiology - Pharmacology ; Medidal Chemistry
R&D Projects	LX22NPO5102 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LTAUSA18083 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Open access
Institutional support	UMCH-V - RVO:61389013 ; MBU-M - RVO:61388971
UT WOS	000992308100001
EID SCOPUS	85143725488
DOI	10.1016/j.jconrel.2022.11.060
Annotation	Nanomedicines are considered next generation therapeutics with advanced therapeutic properties and reduced side effects. Herein, we introduce tailored linear and star-like water-soluble nanosystems as stimuli-sensitive nanomedicines for the treatment of solid tumors or hematological malignancies. The polymer carrier and drug pharmacokinetics were independently evaluated to elucidate the relationship between the nanosystem structure and its distribution in the body. Positron emission tomography and optical imaging demonstrated enhanced tumor accumulation of the polymer carriers in 4T1-bearing mice with increased tumor-to-blood and tumor-to-muscle ratios. Additionally, there was a significant accumulation of doxorubicin bound to various polymer carriers in EL4 tumors, as well as excellent in vivo therapeutic activity in EL4 lymphoma and moderate efficacy in 4T1 breast carcinoma. The linear nanomedicine showed at least comparable pharmacologic properties to the star-like nanomedicines regarding doxorubicin transport. Therefore, if multiple parameters are considered such as its optimized structure and simple and reproducible synthesis, this polymer carrier system is the most promising for further preclinical and clinical investigations.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2024
Electronic address	https://www.sciencedirect.com/science/article/pii/S0168365922008148?via%3Dihub

Number of the records: 1