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Tackling the challenges of group network inference from intracranial EEG data
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SYSNO ASEP 0564952 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Tackling the challenges of group network inference from intracranial EEG data Author(s) Pidnebesna, Anna (UIVT-O) SAI, ORCID, RID
Šanda, Pavel (UIVT-O) SAI, RID
Kalina, A. (CZ)
Hammer, J. (CZ)
Marusič, P. (CZ)
Vlček, Kamil (FGU-C) RID, ORCID
Hlinka, Jaroslav (UIVT-O) RID, SAI, ORCIDArticle number 1061867 Source Title Frontiers in Neuroscience
Roč. 16, 01 December 2022 (2022)Number of pages 19 s. Language eng - English Country CH - Switzerland Keywords connectivity analysis ; Phase Locking Value ; Directed Transfer Function ; intracranial EEG ; information flow ; visual pathways ; ventral visual stream ; dorsal visual stream OECD category Neurosciences (including psychophysiology R&D Projects GA19-11753S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UIVT-O - RVO:67985807 ; FGU-C - RVO:67985823 UT WOS 000897218600001 EID SCOPUS 85144045634 DOI 10.3389/fnins.2022.1061867 Annotation INTRODUCTION: Intracranial EEG (iEEG) data is a powerful way to map brain function, characterized by high temporal and spatial resolution, allowing the study of interactions among neuronal populations that orchestrate cognitive processing. However, the statistical inference and analysis of brain networks using iEEG data faces many challenges related to its sparse brain coverage, and its inhomogeneity across patients. METHODS: We review these challenges and develop a methodological pipeline for estimation of network structure not obtainable from any single patient, illustrated on the inference of the interaction among visual streams using a dataset of 27 human iEEG recordings from a visual experiment employing visual scene stimuli. 100 ms sliding window and multiple band-pass filtered signals are used to provide temporal and spectral resolution. For the connectivity analysis we showcase two connectivity measures reflecting different types of interaction between regions of interest (ROI): Phase Locking Value as a symmetric measure of synchrony, and Directed Transfer Function—asymmetric measure describing causal interaction. For each two channels, initial uncorrected significance testing at p < 0.05 for every time-frequency point is carried out by comparison of the data-derived connectivity to a baseline surrogate-based null distribution, providing a binary time-frequency connectivity map. For each ROI pair, a connectivity density map is obtained by averaging across all pairs of channels spanning them, effectively agglomerating data across relevant channels and subjects. Finally, the difference of the mean map value after and before the stimulation is compared to the same statistic in surrogate data to assess link significance. RESULTS: The analysis confirmed the function of the parieto-medial temporal pathway, mediating visuospatial information between dorsal and ventral visual streams during visual scene analysis. Moreover, we observed the anterior hippocampal connectivity with more posterior areas in the medial temporal lobe, and found the reciprocal information flow between early processing areas and medial place area. DISCUSSION: To summarize, we developed an approach for estimating network connectivity, dealing with the challenge of sparse individual coverage of intracranial EEG electrodes. Its application provided new insights into the interaction between the dorsal and ventral visual streams, one of the iconic dualities in human cognition. Workplace Institute of Computer Science Contact Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800 Year of Publishing 2023 Electronic address https://dx.doi.org/10.3389/fnins.2022.1061867
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