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Age-related metabolic and neurodegenerative changes in SAMP8 mice
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SYSNO ASEP 0563881 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Age-related metabolic and neurodegenerative changes in SAMP8 mice Author(s) Pačesová, A. (CZ)
Holubová, M. (CZ)
Hrubá, L. (CZ)
Strnadová, V. (CZ)
Neprašová, B. (CZ)
Pelantová, H. (CZ)
Kuzma, M. (CZ)
Železná, B. (CZ)
Kuneš, Jaroslav (FGU-C) RID, ORCID
Maletínská, L. (CZ)Source Title Aging. - : Impact Journals LLC - ISSN 1945-4589
Roč. 14, č. 18 (2022), s. 7300-7327Number of pages 28 s. Language eng - English Country US - United States Keywords Alzheimer’s disease ; senescence accelerated mouse prone 8 ; neuroinflammation ; tau pathology ; insulin resistance OECD category Physiology (including cytology) R&D Projects GA20-00546S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 000876483400008 EID SCOPUS 85139572689 DOI 10.18632/aging.204284 Annotation The most important risk factor for the development of sporadic Alzheimer's disease (AD) is ageing. Senescence accelerated mouse prone 8 (SAMP8) is a model of sporadic AD, with senescence accelerated resistant mouse (SAMR1) as a control. In this study, we aimed to determine the onset of senescence-induced neurodegeneration and the related potential therapeutic window using behavioral experiments, immunohistochemistry and western blotting in SAMP8 and SAMR1 mice at 3, 6 and 9 months of age. The Y-maze revealed significantly impaired working spatial memory of SAMP8 mice from the 6th month. With ageing, increasing plasma concentrations of proinflammatory cytokines in SAMP8 mice were detected as well as significantly increased astrocytosis in the cortex and microgliosis in the brainstem. Moreover, from the 3rd month, SAMP8 mice displayed a decreased number of neurons and neurogenesis in the hippocampus. From the 6th month, increased pathological phosphorylation of tau protein at Thr231 and Ser214 was observed in the hippocampi of SAMP8 mice. In conclusion, changes specific for neurodegenerative processes were observed between the 3rd and 6th month of age in SAMP8 mice, thus, potential neuroprotective interventions could be applied between these ages. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2023 Electronic address https://doi.org/10.18632/aging.204284
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