Number of the records: 1
Electrochemistry of Cobalta Bis(dicarbollide) Ions Substituted at Carbon Atoms with Hydrophilic Alkylhydroxy and Carboxy Groups
- 1.
SYSNO ASEP 0561301 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Electrochemistry of Cobalta Bis(dicarbollide) Ions Substituted at Carbon Atoms with Hydrophilic Alkylhydroxy and Carboxy Groups Author(s) Fojt, Lukáš (BFU-R) RID, ORCID
Grüner, Bohumír (UACH-T) RID, SAI, ORCID
Nekvinda, Jan (UACH-T) RID, SAI, ORCID
Tüzün, Ece Zeynep (UACH-T) ORCID, RID, SAI
Havran, Luděk (BFU-R) RID, ORCID
Fojta, Miroslav (BFU-R) RID, ORCIDNumber of authors 6 Article number 1761 Source Title Molecules. - : MDPI
Roč. 27, č. 6 (2022)Number of pages 14 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords metallacarborane ; cobalta bis(dicarbollide) ions ; glassy carbon electrode ; differential pulse voltammetry Subject RIV CE - Biochemistry OECD category Inorganic and nuclear chemistry Subject RIV - cooperation Institute of Inorganic Chemistry - Inorganic Chemistry R&D Projects GA19-04630S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support BFU-R - RVO:68081707 ; UACH-T - RVO:61388980 UT WOS 000776438200001 EID SCOPUS 85126439035 DOI 10.3390/molecules27061761 Annotation In this study we explore the effect on the electrochemical signals in aqueous buffers of the presence of hydrophilic alkylhydroxy and carboxy groups on the carbon atoms of cobalta bis(dicarbollide) ions. The oxygen-containing exo-skeletal substituents of cobalta bis(dicarbollide) ions belong to the perspective building blocks that are considered for bioconjugation. Carbon substitution provides wider versatility and applicability in terms of the flexibility of possible chemical pathways. However, until recently, the electrochemistry of compounds substituted only on boron atoms could be studied, due to the unavailability of carbon-substituted congeners. In the present study, electrochemistry in aqueous phosphate buffers is considered along with the dependence of electrochemical response on pH and concentration. The compounds used show electrochemical signals around1.3 and +1.1 V of similar or slightly higher intensities than in the parent cobalta bis(dicarbollide) ion. The signals at positive electrochemical potential correspond to irreversible oxidation of the boron cage (the C2B9 building block) and at negative potential correspond to the reversible redox process of (CoIII/CoII) at the central atom. Although the first signal is typically sharp and its potential can be altered by a number of substituents, the second signal is complex and is composed of three overlapping peaks. This signal shows sigmoidal character at higher concentrations and may be used as a diagnostic tool for aggregation in solution. Surprisingly enough, the observed effects of the site of substitution (boron or carbon) and between individual groups on the electrochemical response were insignificant. Therefore, the substitutions would preserve promising properties of the parent cage for redox labelling, but would not allow for the further tuning of signal position in the electrochemical window. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2023 Electronic address https://www.mdpi.com/1420-3049/27/6/1761
Number of the records: 1