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Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein

SYSNO ASEP	0560439
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein
Author(s)	Malínská, H. (CZ) Hüttl, M. (CZ) Marková, I. (CZ) Miklánková, D. (CZ) Hojná, Silvie (FGU-C)_{RID, ORCID} Papoušek, František (FGU-C) Šilhavý, Jan (FGU-C)_{RID, ORCID} Mlejnek, Petr (FGU-C)_{RID, ORCID} Zicha, Josef (FGU-C)_{RID, ORCID, SAI} Hrdlička, Jaroslav (FGU-C)_{ORCID, RID} Pravenec, Michal (FGU-C)_{RID, ORCID} Vaněčková, Ivana (FGU-C)_{RID, ORCID}
Article number	2066
Source Title	Biomedicines. - : MDPI Roč. 10, č. 9 (2022)
Number of pages	15 s.
Language	eng - English
Country	CH - Switzerland
Keywords	SHR-CRP ; SGLT-2 inhibitor ; gene expression ; age ; lipid metabolism
OECD category	Physiology (including cytology)
R&D Projects	GA19-06199S GA ČR - Czech Science Foundation (CSF)
	LX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Open access
Institutional support	FGU-C - RVO:67985823
UT WOS	000859391100001
EID SCOPUS	85138637206
DOI	10.3390/biomedicines10092066
Annotation	Gliflozins (inhibitors of sodium-glucose cotransporter 2) show many beneficial actions beyond their antidiabetic effects. The underlying mechanisms of these additional protective effects are still not well understood, especially under non-diabetic conditions. Therefore, we analyzed the effects of empagliflozin in young (3-month-old) and adult (12-month-old) male spontaneously hypertensive rats (SHR) expressing human C-reactive protein (CRP) in the liver. SHR-CRP rats are a non-diabetic model of metabolic syndrome, inflammation, and organ damage. Empagliflozin was given in a daily dose of 10 mg/kg body weight for 8 weeks. Both age groups of SHR-CRP rats treated with empagliflozin had lower body weight, decreased weight of fat depots, reduced ectopic fat accumulation in the liver and kidneys, and decreased levels of plasma insulin and beta-hydroxybutyrate. Empagliflozin effectively reduced ectopic renal fat accumulation, and was associated with decreased inflammation. Exclusively in young rats, decreased microalbuminuria after empagliflozin treatment was accompanied by attenuated oxidative stress. In adult animals, empagliflozin also improved left ventricle function. In conclusion, in young animals, the beneficial renoprotective effects of empagliflozin could be ascribed to reduced lipid deposition in the kidney and the attenuation of oxidative stress and inflammation. In contrast, hepatic lipid metabolism was ameliorated in adult rats.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2023
Electronic address	https://www.mdpi.com/2227-9059/10/9/2066

Number of the records: 1