Revisiting bioactivity of calcium titanate and titanium dioxide: Hydrolysis and complexation effects in osteogenic medium

Křenek, T.; Stich, T.; Docheva, D.; Mikysek, Petr; Koštejn, Martin; Jandová, Věra; Fajgar, Radek; Pola, M.; Kovářík, T.; Moskal, D.; Forejtová, M.; Pola, Josef

doi:https://dx.doi.org/10.1016/j.surfcoat.2022.128820

Number of the records: 1

Revisiting bioactivity of calcium titanate and titanium dioxide: Hydrolysis and complexation effects in osteogenic medium

1.

SYSNO ASEP	0560435
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Revisiting bioactivity of calcium titanate and titanium dioxide: Hydrolysis and complexation effects in osteogenic medium
Author(s)	Křenek, T. (CZ) Stich, T. (DE) Docheva, D. (DE) Mikysek, Petr (GLU-S)_{SAI, ORCID} Koštejn, Martin (UCHP-M)_{RID, SAI, ORCID} Jandová, Věra (UCHP-M)_{RID, ORCID, SAI} Fajgar, Radek (UCHP-M)_{RID, ORCID, SAI} Pola, M. (CZ) Kovářík, T. (CZ) Moskal, D. (CZ) Forejtová, M. (CZ) Pola, Josef (UCHP-M)_{RID, ORCID, SAI}
Article number	128820
Source Title	Surface and Coatings Technology. - : Elsevier - ISSN 0257-8972 Roč. 447, October (2022)
Number of pages	10 s.
Publication form	Print - P
Language	eng - English
Country	CH - Switzerland
Keywords	Calcium titanate coat ; Hydrolysis ; Micro/nanostructured oxidic titanium ; hMSCs ; Osteogenic differentiation ; DMEM-TiO₂ interactions ; Self-organized precipitation of DMEM
OECD category	Mineralogy
Method of publishing	Limited access
Institutional support	GLU-S - RVO:67985831 ; UCHP-M - RVO:67985858
UT WOS	000853444000001
EID SCOPUS	85137110806
DOI	10.1016/j.surfcoat.2022.128820
Annotation	This study characterized laser-deposited CaTiO₃ coats on several substrates by electron microscopy, X-ray diffraction, and Raman spectra. The hydrolytic stability of such coats exposed to ambient air and immersed into culture and osteogenic media has been respectively assessed by X-ray photoelectron spectra and energy dispersive X-ray analysis. It is shown these coats on titanium and micro/nanostructured oxidic titanium are not stable in air and culture or osteogenic media where they undergo hydrolysis and Ca leakage. The role of this hydrolysis is assessed and discussed in terms of not yet acknowledged complexation of the developing TiO₂ surface with constituents of Dulbecco's Modified Eagle's medium. The effect of the deposited and additionally heated CT coatings on human mesenchymal stem cells is assessed regarding survival, proliferation and differentiation towards the osteogenic lineage in osteogenic medium. It is also stressed that the identified CaTiO₃ hydrolysis in air and aquatic media seriously impacts the interpretation of bioactivity and physicochemical, catalytic and photocatalytic properties of CaTiO₃ surfaces, which has not been yet admitted and led to erroneous conclusions in many previous studies.
Workplace	Institute of Geology
Contact	Jana Popelková, popelkova@gli.cas.cz, Sabina Janíčková, Tel.: 233 087 272
Year of Publishing	2023
Electronic address	https://www.sciencedirect.com/science/article/pii/S0257897222007411

Number of the records: 1