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Quorum-sensing signals from epibiont mediate the induction of novel microviridins in the mat-forming cyanobacterial genus Nostoc.
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SYSNO ASEP 0560152 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Quorum-sensing signals from epibiont mediate the induction of novel microviridins in the mat-forming cyanobacterial genus Nostoc. Author(s) Saha, S. (CZ)
Bulzu, Paul-Adrian (BC-A) RID
Urajová, P. (CZ)
Mareš, Jan (BC-A) RID, ORCID
Konert, G. (CZ)
Manoel, J.C. (CZ)
Macho, M. (CZ)
Ewe, D. (CZ)
Hrouzek, P. (CZ)
Masojídek, J. (CZ)
Ghai, Rohit (BC-A) RID, ORCID
Saurav, K. (CZ)Number of authors 12 Article number e00562-21 Source Title mSphere. - : American Society for Microbiology - ISSN 2379-5042
Roč. 6, č. 4 (2021)Number of pages 5 s. Language eng - English Country US - United States Keywords cyanobacteria ; cyanopeptides ; homoserine lactones ; microviridin ; quorum sensing Subject RIV EE - Microbiology, Virology OECD category Microbiology R&D Projects GX20-12496X GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support BC-A - RVO:60077344 UT WOS 000709928000021 EID SCOPUS 85115040293 DOI 10.1128/mSphere.00562-21 Annotation The regulation of the production of oligopeptides is essential in understanding their ecological role in complex microbial communities, including harmful cyanobacterial blooms. The role of chemical communication between the cyanobacterium and the microbial community harbored as epibionts within its phycosphere is at an initial stage of research, and little is understood about its specificity. Here, we present insight into the role of a bacterial epibiont in regulating the production of novel microviridins isolated from Nostoc, an ecologically important cyanobacterial genus. Microviridins are well-known elastase inhibitors with presumed antigrazing effects. Heterologous expression and identification of specific signal molecules from the epibiont suggest the role of a quorum-sensing-based interaction. Furthermore, physiological experiments show an increase in microviridin production without affecting cyanobacterial growth and photosynthetic activity. Simultaneously, oligopeptides presenting a selective inhibition pattern provide support for their specific function in response to the presence of cohabitant epibionts. Thus, the chemical interaction revealed in our study provides an example of an interspecies signaling pathway monitoring the bacterial flora around the cyanobacterial filaments and the induction of intrinsic species-specific metabolic responses. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2022 Electronic address https://doi.org/10.1128/mSphere.00562-21
Number of the records: 1