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Serological Markers of Intestinal Barrier Impairment do not Correlate With Duration of Diabetes and Glycated Hemoglobin in Adult Patients With Type 1 and Type 2 Diabetes Mellitus
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SYSNO ASEP 0560087 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Serological Markers of Intestinal Barrier Impairment do not Correlate With Duration of Diabetes and Glycated Hemoglobin in Adult Patients With Type 1 and Type 2 Diabetes Mellitus Author(s) Hoffmanová, I. (CZ)
Sánchez, Daniel (MBU-M) RID
Szczepanková, Adéla (MBU-M)
Hábová, Věra (MBU-M) RID
Tlaskalová-Hogenová, Helena (MBU-M) RID, ORCIDSource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 71, č. 3 (2022), s. 357-368Number of pages 12 s. Language eng - English Country CZ - Czech Republic Keywords Cytokeratin 18 caspase-cleaved fragment ; Diabetes mellitus ; Glycated hemoglobin ; Intestinal barrier ; Intestinal fatty acid-binding protein ; Soluble CD14 Subject RIV EE - Microbiology, Virology OECD category Microbiology R&D Projects NV18-05-00394 GA MZd - Ministry of Health (MZ) Method of publishing Open access Institutional support MBU-M - RVO:61388971 UT WOS 000834626200002 EID SCOPUS 85135514296 DOI 10.33549/physiolres.934874 Annotation Growing evidence suggests that diabetes mellitus is associated with impairment of the intestinal barrier. However, it is not clear so far if the impairment of the intestinal barrier is a consequence of prolonged hyperglycemia or the consequence of external factors influencing the gut microbiota and intestinal mucosa integrity. Aim of the study was to perform an estimation of relationship between serological markers of impairment of the intestinal barrier: intestinal fatty acid-binding protein (I-FABP), cytokeratin 18 caspase-cleaved fragment (cCK-18), and soluble CD14 (sCD14) and markers of prolonged hyperglycemia, such as the duration of diabetes mellitus and glycated hemoglobin (HbA1c) via a correlation analysis in patients with diabetes mellitus. In 40 adult patients with type 1 diabetes mellitus and 30 adult patients with type 2 diabetes mellitus the estimation has been performed. Statistically significant positive correlation was found between cCK-18 and HbA1c (r=0.5047, p=0.0275) in patients with type 1 diabetes mellitus with fading insulitis (T1D). In patients with type 1 diabetes mellitus with ongoing insulitis (T1D/INS) and in patients with type 2 diabetes mellitus (T2D), no statistically significant positive correlations were found between serological markers of intestinal barrier impairment (I-FABP, cCK-18, sCD14) and duration of diabetes or levels of HbA1c. Similarly, in cumulative cohort of patients with T1D/INS and patients with T1D we revealed statistically positive correlation only between HbA1c and cCK-18 (r=0.3414, p=0.0311). Surprisingly, we found statistically significant negative correlation between the duration of diabetes mellitus and cCK-18 (r=-0.3050, p=0.0313) only in cumulative group of diabetic patients (T1D, T1D/INS, and T2D). Based on our results, we hypothesize that the actual condition of the intestinal barrier in diabetic patients is much more dependent on variable interactions between host genetic factors, gut microbiota, and environmental factors rather than effects of long-standing hyperglycemia (assessed by duration of diabetes mellitus or HbA1c). Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2023 Electronic address https://www.biomed.cas.cz/physiolres/pdf/2022/71_357.pdf
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