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Biocompatible hydrogels based on chitosan, cellulose/starch, PVA and PEDOT:PSS with high flexibility and high mechanical strength
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SYSNO ASEP 0559150 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Biocompatible hydrogels based on chitosan, cellulose/starch, PVA and PEDOT:PSS with high flexibility and high mechanical strength Author(s) Dodda, J. M. (CZ)
Azar, M. G. (CZ)
Bělský, P. (CZ)
Šlouf, Miroslav (UMCH-V) RID, ORCID
Brož, Antonín (FGU-C) RID, ORCID, SAI
Bačáková, Lucie (FGU-C) RID, ORCID
Kadlec, J. (CZ)
Remiš, T. (CZ)Source Title Cellulose. - : Springer - ISSN 0969-0239
Roč. 29, č. 12 (2022), s. 6697-6717Number of pages 21 s. Language eng - English Country NL - Netherlands Keywords nulticomponent hydrogel ; cellulose/starch ; chitosan OECD category Polymer science Subject RIV - cooperation Institute of Macromolecular Chemistry - Macromolecular Chemistry
Institute of Physiology - Biotechnology ; BionicsR&D Projects GA20-01641S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 ; FGU-C - RVO:67985823 UT WOS 000815422900001 EID SCOPUS 85132706794 DOI 10.1007/s10570-022-04686-4 Annotation Fabricating mechanically strong hydrogels that can withstand the conditions in internal tissues is a challenging task. We have designed hydrogels based on multicomponent systems by combining chitosan, starch/cellulose, PVA, and PEDOT:PSS via one-pot synthesis. The starch-based hydrogels were homogeneous, while the cellulose-based hydrogels showed the presence of cellulose micro- and nanofibers. The cellulose-based hydrogels demonstrated a swelling ratio between 121 and 156%, while the starch-based hydrogels showed higher values, from 234 to 280%. Tensile tests indicated that the presence of starch in the hydrogels provided high flexibility (strain at break > 300%), while combination with cellulose led to the formation of stiffer hydrogels (elastic moduli 3.9–6.6 MPa). The ultimate tensile strength for both types of hydrogels was similar (2.8–3.9 MPa). The adhesion and growth of human osteoblast-like SAOS-2 cells was higher on hydrogels with cellulose than on hydrogels with starch, and was higher on hydrogels with PEDOT:PSS than on hydrogels without this polymer. The metabolic activity of cells cultivated for 3 days in the hydrogel infusions indicated that no acutely toxic compounds were released. This is promising for further possible applications of these hydrogels in tissue engineering or in wound dressings. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2023 Electronic address https://link.springer.com/article/10.1007/s10570-022-04686-4
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