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Paramagnetic encoding of molecules
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SYSNO ASEP 0558685 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Paramagnetic encoding of molecules Author(s) Kretschmer, Jan (UOCHB-X)
David, Tomáš (UOCHB-X) RID, ORCID
Dračínský, Martin (UOCHB-X) RID, ORCID
Socha, Ondřej (UOCHB-X) ORCID, RID
Jirák, D. (CZ)
Vít, M. (CZ)
Jurok, R. (CZ)
Kuchař, M. (CZ)
Císařová, I. (CZ)
Polášek, Miloslav (UOCHB-X) ORCIDArticle number 3179 Source Title Nature Communications. - : Nature Publishing Group
Roč. 13, č. 1 (2022)Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords solid-phase synthesis ; contrast agents ; information OECD category Organic chemistry R&D Projects GJ17-22834Y GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UOCHB-X - RVO:61388963 UT WOS 000809119000011 EID SCOPUS 85131622648 DOI 10.1038/s41467-022-30811-9 Annotation Contactless digital tags are increasingly penetrating into many areas of human activities. Digitalization of our environment requires an ever growing number of objects to be identified and tracked with machine-readable labels. Molecules offer immense potential to serve for this purpose, but our ability to write, read, and communicate molecular code with current technology remains limited. Here we show that magnetic patterns can be synthetically encoded into stable molecular scaffolds with paramagnetic lanthanide ions to write digital code into molecules and their mixtures. Owing to the directional character of magnetic susceptibility tensors, each sequence of lanthanides built into one molecule produces a unique magnetic outcome. Multiplexing of the encoded molecules provides a high number of codes that grows double-exponentially with the number of available paramagnetic ions. The codes are readable by nuclear magnetic resonance in the radiofrequency (RF) spectrum, analogously to the macroscopic technology of RF identification. A prototype molecular system capable of 16-bit (65,535 codes) encoding is presented. Future optimized systems can conceivably provide 64-bit (~10^19 codes) or higher encoding to cover the labelling needs in drug discovery, anti-counterfeiting and other areas. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2023 Electronic address https://doi.org/10.1038/s41467-022-30811-9
Number of the records: 1