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Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase

SYSNO ASEP	0557890
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase
Author(s)	Brejchová, Kristýna (FGU-C)_{ORCID, RID, SAI} Palůchová, Veronika (FGU-C)_{ORCID, RID} Březinová, Marie (FGU-C)_ORCID Čajka, Tomáš (FGU-C)_{RID, ORCID, SAI} Balas, L. (FR) Durand, T. (FR) Křížová, M. (CZ) Straňák, Z. (CZ) Kuda, Ondřej (FGU-C)_{RID, ORCID, SAI}
Article number	132983
Source Title	Food Chemistry. - : Elsevier - ISSN 0308-8146 Roč. 388, Sep 15 (2022)
Number of pages	9 s.
Language	eng - English
Country	NL - Netherlands
Keywords	human breast milk ; lipidomics ; PAHSA ; colostrum ; elective caesarean section ; preterm birth
OECD category	Biochemistry and molecular biology
R&D Projects	GA20-00317S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	FGU-C - RVO:67985823
UT WOS	000803035900004
EID SCOPUS	85130638484
DOI	10.1016/j.foodchem.2022.132983
Annotation	Breast milk is a complex mixture containing underexplored bioactive lipids. We performed an observational case-control study to compare the impact of delivery mode: caesarean section (CS) and vaginal birth (VB), and term (preterm and term delivery) on the levels of lipokines in human milk at different stages of lactation. Metabolomic analysis of the milk identified triacylglycerol estolides as a metabolic reservoir of the anti-inflammatory lipid mediator 5-palmitic acid ester of hydroxystearic acid (5-PAHSA). We found that triacylglycerol estolides were substrates of carboxyl ester lipase and 5-PAHSA-containing lipids were the least preferred substrates among tested triacylglycerol estolide isomers. This explained exceptionally high colostrum levels of 5-PAHSA in the VB group. CS and preterm birth negatively affected colostrum lipidome, including 5-PAHSA levels, but the lipidomic profiles normalized in mature milk. Mothers delivering term babies vaginally produce colostrum rich in 5-PAHSA, which could contribute to the prevention of intestinal inflammation in newborns.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2023
Electronic address	https://doi.org/10.1016/j.foodchem.2022.132983

Number of the records: 1