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Mitochondrial respiration supports autophagy to provide stress resistance during quiescence
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SYSNO ASEP 0557875 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mitochondrial respiration supports autophagy to provide stress resistance during quiescence Author(s) Magalhaes-Novais, Silvia (BTO-N) ORCID
Blecha, Jan (BTO-N)
Naraine, Ravindra (BTO-N)
Mikesova, Jana (BTO-N)
Abaffy, Pavel (BTO-N)
Pecinová, Alena (FGU-C) RID, ORCID, SAI
Miloševič, Mirko (BTO-N)
Bohuslavová, Romana (BTO-N) RID
Procházka, Jan (UMG-J) ORCID
Khan, S. (BE)
Novotná, Eliška (BTO-N)
Šindelka, Radek (BTO-N) RID
Machan, R. (BE)
Dewerchin, M. (BE)
Vlčák, Erik (UMG-J)
Kalucka, J. (BE)
Štemberková-Hubáčková, Soňa (BTO-N)
Benda, A. (CZ)
Goveia, J. (BE)
Mráček, Tomáš (FGU-C) RID, ORCID
Bařinka, Cyril (BTO-N) RID, ORCID
Carmeliet, P. (BE)
Neužil, Jiří (BTO-N) RID
Rohlenová, Kateřina (BTO-N) ORCID, RID
Rohlena, Jakub (BTO-N) RID, ORCIDNumber of authors 25 Source Title Autophagy. - : Taylor & Francis - ISSN 1554-8627
Roč. 18, č. 10 (2022), s. 2409-2426Number of pages 19 s. Language eng - English Country US - United States Keywords ATG4B ; cell death ; biosynthesis ; electron transport chain Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology R&D Projects GA20-18513S GA ČR - Czech Science Foundation (CSF) GA17-24441S GA ČR - Czech Science Foundation (CSF) GA20-05942S GA ČR - Czech Science Foundation (CSF) GA18-02550S GA ČR - Czech Science Foundation (CSF) GX21-04607X GA ČR - Czech Science Foundation (CSF) GA22-34507S GA ČR - Czech Science Foundation (CSF) NV17-30138A GA MZd - Ministry of Health (MZ) NV17-32727A GA MZd - Ministry of Health (MZ) NU21-03-00545 GA MZd - Ministry of Health (MZ) NU20J-02-00035 GA MZd - Ministry of Health (MZ) LM2018129 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2015040 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2018126 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF18_046/0015861 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF16_013/0001775 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF18_046/0016045 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Research Infrastructure Czech-BioImaging II - 90129 - Ústav molekulární genetiky AV ČR, v. v. i.
CCP II - 90126 - Ústav molekulární genetiky AV ČR, v. v. i.Method of publishing Open access Institutional support BTO-N - RVO:86652036 ; UMG-J - RVO:68378050 ; FGU-C - RVO:67985823 UT WOS 000766134900001 EID SCOPUS 85126384039 DOI 10.1080/15548627.2022.2038898 Annotation Mitochondrial oxidative phosphorylation (OXPHOS) generates ATP, but OXPHOS also supports biosynthesis during proliferation. In contrast, the role of OXPHOS during quiescence, beyond ATP production, is not well understood. Using mouse models of inducible OXPHOS deficiency in all cell types or specifically in the vascular endothelium that negligibly relies on OXPHOS-derived ATP, we show that selectively during quiescence OXPHOS provides oxidative stress resistance by supporting macroautophagy/autophagy. Mechanistically, OXPHOS constitutively generates low levels of endogenous ROS that induce autophagy via attenuation of ATG4B activity, which provides protection from ROS insult. Physiologically, the OXPHOS-autophagy system (i) protects healthy tissue from toxicity of ROS-based anticancer therapy, and (ii) provides ROS resistance in the endothelium, ameliorating systemic LPS-induced inflammation as well as inflammatory bowel disease. Hence, cells acquired mitochondria during evolution to profit from oxidative metabolism, but also built in an autophagy-based ROS-induced protective mechanism to guard against oxidative stress associated with OXPHOS function during quiescence. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2023 Electronic address https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2038898
Number of the records: 1