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Evaluation of estrogenic and antiestrogenic activity in sludge and explanation of individual compound contributions

SYSNO ASEP	0557651
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Evaluation of estrogenic and antiestrogenic activity in sludge and explanation of individual compound contributions
Author(s)	Černá, Tereza (MBU-M) Ezechiáš, Martin (MBU-M)_RID Semerád, Jaroslav (MBU-M)_{ORCID, RID} Grasserová, Alena (MBU-M)_ORCID Cajthaml, Tomáš (MBU-M)_{RID, ORCID}
Article number	127108
Source Title	Journal of Hazardous Materials. - : Elsevier - ISSN 0304-3894 Roč. 423, FEB 5 2022 (2022)
Number of pages	10 s.
Language	eng - English
Country	NL - Netherlands
Keywords	effect-directed analysis ; municipal waste-water ; generalized concentration addition ; reporter gene assay ; sewage-sludge ; bisphenol analogs ; environmental estrogens ; androgenic activity ; endocrine activity ; steroid estrogens ; WWTP sludge ; Mixture toxicity ; Constructed wetland ; Agonistic activity ; Antagonistic activity
Subject RIV	EH - Ecology, Behaviour
OECD category	Environmental sciences (social aspects to be 5.7)
Method of publishing	Limited access
Institutional support	MBU-M - RVO:61388971
UT WOS	000696981500003
EID SCOPUS	85114679051
DOI	10.1016/j.jhazmat.2021.127108
Annotation	Mixture toxicity, including agonistic and antagonistic effects, is an unrevealed environmental problem. Estrogenic endocrine disruptors are known to cause adverse effects for aquatic biota, but causative chemicals and their contributions to the total activity in sewage sludge remain unknown. Therefore, advanced analytical methods, a yeast bioassay and mixture toxicity models were concurrently applied for the characterization of 8 selected sludges with delectable estrogenic activity (and 3 sludges with no activity as blanks) out of 25 samples from wastewater treatment plants (WWTPs). The first applied full logistic model adequately explained total activity by considering the concentrations of the monitored compounds. The results showed that the activity was primarily caused by natural estrogens in municipal WWTP sludge. Nevertheless, activity in a sample originating from a car wash facility was dominantly caused by partial agonists nonylphenols and only a model enabling prediction of all dose-response curve parameters of the final mixture curve explained these results. Antiestrogenic effects were negligible, and effect-directed analysis identified the causative chemicals.
Workplace	Institute of Microbiology
Contact	Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231
Year of Publishing	2023
Electronic address	https://www.sciencedirect.com/science/article/pii/S0304389421020768?via%3Dihub

Number of the records: 1