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Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension
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SYSNO ASEP 0557493 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension Author(s) Kurtz, T. W. (US)
Pravenec, Michal (FGU-C) RID, ORCID
DiCarlo, S. E. (US)Source Title Clinical science. - : Portland Press - ISSN 0143-5221
Roč. 136, č. 8 (2022), s. 599-620Number of pages 22 s. Language eng - English Country GB - United Kingdom Keywords blood pressure ; hypertension ; nitrate ; salt ; sodium ; sodium chloride OECD category Cardiac and Cardiovascular systems Method of publishing Open access Institutional support FGU-C - RVO:67985823 UT WOS 000791800700005 EID SCOPUS 85129778275 DOI 10.1042/CS20210566 Annotation High-salt diets are a major cause of hypertension and cardiovascular (CV) disease. Many governments are interested in using food salt reduction programs to reduce the risk for salt-induced increases in blood pressure and CV events. It is assumed that reducing the salt concentration of processed foods will substantially reduce mean salt intake in the general population. However, contrary to expectations, reducing the sodium density of nearly all foods consumed in England by 21% had little or no effect on salt intake in the general population. This may be due to the fact that in England, as in other countries including the U.S.A., mean salt intake is already close to the lower normal physiologic limit for mean salt intake of free-living populations. Thus, mechanism-based strategies for preventing salt-induced increases in blood pressure that do not solely depend on reducing salt intake merit attention. It is now recognized that the initiation of salt-induced increases in blood pressure often involves a combination of normal increases in sodium balance, blood volume and cardiac output together with abnormal vascular resistance responses to increased salt intake. Therefore, preventing either the normal increases in sodium balance and cardiac output, or the abnormal vascular resistance responses to salt, can prevent salt-induced increases in blood pressure. Suboptimal nutrient intake is a common cause of the hemodynamic disturbances mediating salt-induced hypertension. Accordingly, efforts to identify and correct the nutrient deficiencies that promote salt sensitivity hold promise for decreasing population risk of salt-induced hypertension without requiring reductions in salt intake. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2023 Electronic address https://doi.org/10.1042/CS20210566
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