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Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics
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SYSNO ASEP 0557115 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics Author(s) Markowicz-Piasecka, M. (PL)
Markiewicz, A. (PL)
Darlak, P. (PL)
Sikora, J. (PL)
Adla, Santosh Kumar (UOCHB-X) ORCID
Bagina, S. (FI)
Huttunen, K. M. (FI)Source Title Neurotherapeutics. - : Springer - ISSN 1933-7213
Roč. 19, č. 3 (2022), s. 942-976Number of pages 35 s. Language eng - English Country US - United States Keywords brain-blood barrier ; prodrug approach ; carrier-mediated transport ; receptor-mediated transport ; drug delivery OECD category Biochemistry and molecular biology Method of publishing Limited access Institutional support UOCHB-X - RVO:61388963 UT WOS 000779225400001 EID SCOPUS 85128867471 DOI 10.1007/s13311-022-01228-5 Annotation One of the greatest challenges with successful pharmaceutical treatments of central nervous system (CNS) diseases is the delivery of drugs into their target sites with appropriate concentrations. For example, the physically tight blood-brain barrier (BBB) effectively blocks compounds from penetrating into the brain, also by the action of metabolizing enzymes and efflux transport mechanisms. However, many endogenous compounds, including both smaller compounds and macromolecules, like amino acids, sugars, vitamins, nucleosides, hormones, steroids, and electrolytes, have their peculiar internalization routes across the BBB. These delivery mechanisms, namely carrier-mediated transport and receptor-mediated transcytosis have been utilized to some extent in brain-targeted drug development. The incomplete knowledge of the BBB and the smaller than a desirable number of chemical tools have hindered the development of successful brain-targeted pharmaceutics. This review discusses the recent advancements achieved in the field from the point of medicinal chemistry view and discusses how brain drug delivery can be improved in the future. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2023 Electronic address https://doi.org/10.1007/s13311-022-01228-5
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